- Substituted piperidines as therapeutic compounds
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Described are compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R2, R3, W,and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II an
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- Substituted Piperidines as Renin Inhibitors
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Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.
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Page/Page column 50-51
(2009/12/24)
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- Substituted piperidines as therapeutic compounds
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Use of compounds of the general formula (1) and pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, W, X, Z and n have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.
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Page/Page column 31
(2008/12/08)
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- Organic compounds
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The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.
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Page/Page column 29
(2010/11/30)
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- SUBSTITUTED 4-PHENYLPIPERIDINES
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The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R2, R3, W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
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Page/Page column 49
(2008/06/13)
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- 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS
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The application relates to novel substituted piperidines of the general formula (II) in which R1, R2', R2'', R4', X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.
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Page/Page column 46
(2008/06/13)
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