873945-27-8

Usage

Uses

Used in Pharmaceutical Industry:
Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to be modified and incorporated into various drug molecules. Its unique stereochemistry and functional groups allow for the creation of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate is used as a precursor in the development of novel agrochemicals, such as pesticides and herbicides. Its structural features enable the design of molecules with targeted biological activity and improved environmental compatibility.
Used in Materials Industry:
Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate is utilized as a component in the synthesis of advanced materials, including polymers and coatings. Its functional groups and stereochemistry contribute to the development of materials with specific properties, such as improved durability, adhesion, or biocompatibility.

Upstream product

• 873945-31-4 (3R,4R,5S)-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidin-3-ol 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 873946-14-6 benzyl (3R,4R,5S)-3-hydroxy-4-(4-methoxycarbonylphenyl)-5-triisopropylsilanyl-oxypiperidine-1-carboxylate 
• 912346-39-5 benzyl (3R,4R,5S)-3-hydroxy-5-triisopropylsilanyloxy-4-(4-vinylphenyl)-piperidine-1-carboxylate 
• 944954-10-3 (3R,4R,5S)-4-[4-(4-methoxy-butoxy)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 
• 873945-60-9 benzyl (3R,4R,5S)-3-hydroxy-4-(4-methoxyphenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate 
• 873946-15-7 benzyl (3R,4R,5S)-3-hydroxy-4-(4-trifluoromethanesulphonyloxyphenyl)-5-triisopropylsilanyloxy-piperidine-1-carboxylate 
• 912346-47-5 (3R,4R,5S)-4-(4-allyloxy-phenyl)-3-hydroxy-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 
• 944953-38-2 benzyl (3R,4R,5S)-3-hydroxy-4-[4-(3-methoxypropoxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate 
• 1006865-28-6 (3R,4R,5S)-3-hydroxy-4-[4-(4-methoxy-butoxy)-phenyl]-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Substituted piperidines as therapeutic compounds

Described are compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R2, R3, W,and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II an

Substituted Piperidines as Renin Inhibitors

Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.

Substituted piperidines as therapeutic compounds

Use of compounds of the general formula (1) and pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, W, X, Z and n have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

Organic compounds

The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.

SUBSTITUTED 4-PHENYLPIPERIDINES

The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R2, R3, W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.

3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS

The application relates to novel substituted piperidines of the general formula (II) in which R1, R2', R2'', R4', X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.