873945-27-8

Basic information

• Product Name: Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate
• Synonyms: 1-Piperidinecarboxylicacid,3-hydroxy-4-(4-hydroxyphenyl)-5-[[tris(1-methylethyl)silyl]oxy]-,phenylmethylester,(3R,4R,5S)-;Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate;(3R,4R,5S)-3-Hydroxy-4-(4-hydroxyphenyl)-5-[[tris(1-methylethyl)silyl]oxy]-1-piperidinecarboxylic acid phenylmethyl ester;(3R,4R,5S)-Benzyl 3-hydroxy-4-(4-hydroxyphenyl)-5-((triisopropylsilyl)oxy)piperidine-1-Carboxylat;(3R,4R,5S)-Benzyl 3-hydroxy-4-(4-hydroxyphenyl)-5-((triisopropylsilyl)oxy)piperidine-1-Carboxy;(3R,4R,5S)-Benzyl 3-hydroxy-4-(4-hydroxyphenyl)-5-((triisopropylsilyl)oxy)piperidine-1-Carboxylate
• CAS NO: 873945-27-8
• Molecular Formula: C₂₈H₄₁NO₅Si
• Molecular Weight: 499.71434
• Mol File: 873945-27-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 592.849 °C at 760 mmHg
• Flash Point: 312.344 °C
• Appearance: /
• Density: 1.13
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate(873945-27-8)
• EPA Substance Registry System: Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate(873945-27-8)

Safety Data

• Hazardous Substances Data: 873945-27-8(Hazardous Substances Data)

Usage

General Description

Benzyl(3R,4R,5S)-3-hydroxy-4-(4-hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidine-1-carboxylate is a chemical compound with a complex structure. It consists of a piperidine ring with hydroxy and benzyl groups attached, as well as a carboxylate ester and triisopropylsilane groups. The compound is a piperidine carboxylate derivative and is commonly used in organic chemistry synthesis. Its specific stereochemistry and functional groups make it a valuable tool for creating and modifying molecules for various applications in the pharmaceutical, agrochemical, and materials industries.

Upstream product

• 873945-31-4 (3R,4R,5S)-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidin-3-ol 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 873946-14-6 benzyl (3R,4R,5S)-3-hydroxy-4-(4-methoxycarbonylphenyl)-5-triisopropylsilanyl-oxypiperidine-1-carboxylate 
• 912346-39-5 benzyl (3R,4R,5S)-3-hydroxy-5-triisopropylsilanyloxy-4-(4-vinylphenyl)-piperidine-1-carboxylate 
• 1006865-28-6 (3R,4R,5S)-3-hydroxy-4-[4-(4-methoxy-butoxy)-phenyl]-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 
• 912346-47-5 (3R,4R,5S)-4-(4-allyloxy-phenyl)-3-hydroxy-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 
• 873946-15-7 benzyl (3R,4R,5S)-3-hydroxy-4-(4-trifluoromethanesulphonyloxyphenyl)-5-triisopropylsilanyloxy-piperidine-1-carboxylate 
• 944954-10-3 (3R,4R,5S)-4-[4-(4-methoxy-butoxy)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 
• 873945-60-9 benzyl (3R,4R,5S)-3-hydroxy-4-(4-methoxyphenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate 
• 944953-38-2 benzyl (3R,4R,5S)-3-hydroxy-4-[4-(3-methoxypropoxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate 

Relevant articles and documents

Substituted piperidines as therapeutic compounds

Described are compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R2, R3, W,and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II an

Substituted piperidines as therapeutic compounds

Use of compounds of the general formula (1) and pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, W, X, Z and n have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

SUBSTITUTED 4-PHENYLPIPERIDINES

The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R2, R3, W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.