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Pyridine-2-boronic acid pinacol ester is an organic compound that serves as a versatile building block in organic synthesis. It is a white to light yellow crystalline powder, known for its reactivity and stability, making it a valuable intermediate in the synthesis of various pharmaceuticals and organic compounds.

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  • 874186-98-8 Structure
  • Basic information

    1. Product Name: Pyridine-2-boronic acid pinacol ester
    2. Synonyms: 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;Pyridine-2-boronic acid pinacol ester;Albb-006131;BP1166pyridine-2boronicacidpinacolester;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(Pyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(2-pyridyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;Pyridine, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen pyridin-2-ylboronate
    3. CAS NO:874186-98-8
    4. Molecular Formula: C11H18BNO3
    5. Molecular Weight: 223.08
    6. EINECS: 1533716-785-6
    7. Product Categories: N/A
    8. Mol File: 874186-98-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 300.9 °C at 760 mmHg
    3. Flash Point: 135.8 °C
    4. Appearance: white to light yellow crystal powde
    5. Density: 1.03 g/cm3
    6. Vapor Pressure: 2E-05mmHg at 25°C
    7. Refractive Index: 1.501
    8. Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
    9. Solubility: N/A
    10. PKA: 5.26±0.19(Predicted)
    11. CAS DataBase Reference: Pyridine-2-boronic acid pinacol ester(CAS DataBase Reference)
    12. NIST Chemistry Reference: Pyridine-2-boronic acid pinacol ester(874186-98-8)
    13. EPA Substance Registry System: Pyridine-2-boronic acid pinacol ester(874186-98-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 874186-98-8(Hazardous Substances Data)

874186-98-8 Usage

Uses

Used in Pharmaceutical Industry:
Pyridine-2-boronic acid pinacol ester is used as a reactant for the preparation of aminooxazoline azaxanthenes, which are oral β-secretase inhibitors. These inhibitors are crucial in Alzheimer's therapy, as they help regulate the production of amyloid-beta peptides, a key factor in the development of Alzheimer's disease.
Additionally, due to its unique chemical properties and reactivity, Pyridine-2-boronic acid pinacol ester can be employed in the synthesis of other bioactive compounds and pharmaceuticals, contributing to the development of new drugs and therapeutic agents in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 874186-98-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,1,8 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 874186-98:
(8*8)+(7*7)+(6*4)+(5*1)+(4*8)+(3*6)+(2*9)+(1*8)=218
218 % 10 = 8
So 874186-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H16BNO2/c1-10(2,14)11(3,4)16-12(15)9-7-5-6-8-13-9/h5-8,14-15H,1-4H3

874186-98-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Pyridine-2-boronic acid pinacol ester

1.2 Other means of identification

Product number -
Other names 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:874186-98-8 SDS

874186-98-8Relevant articles and documents

Cationic magnesium hydride [MgH]+ stabilized by an NNNN-type macrocycle

Lemmerz, Lara E.,Mukherjee, Debabrata,Spaniol, Thomas P.,Wong, Anthony,Ménard, Gabriel,Maron, Laurent,Okuda, Jun

supporting information, p. 3199 - 3202 (2019/05/08)

A magnesium hydride cation [(L)MgH]+ supported by a macrocyclic ligand (L = Me4TACD; 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane) has been prepared by partial protonolysis of a mixed amide hydride [(L)MgH2Mg{N(SiMe3)2}2] and shown to undergo a variety of reactions with unsaturated substrates, including pyridine.

Anthracene organic luminescence compound, and preparation method and application thereof

-

Paragraph 0109-0116, (2019/07/01)

The invention relates to the technical field of organic optoelectronic materials and relates to an anthracene organic luminescence compound, a preparation method thereof and an organic electroluminescence device. The anthracene organic luminescence compound has a structure shown as a formula I: the formula 1 is shown in the description. Compared with other electron transfer layer materials or luminescent layer materials, the novel anthracene organic luminescence compound provided by the invention used as an electron transfer layer material or luminescent layer material of the organic electroluminescence device has the advantage that the luminous efficiency of the device prepared from the material is obviously promoted, and service life is obviously prolonged. The anthracene organic luminescence compound has the advantages of relatively short synthetic route, simple process, easily acquired raw materials, low cost and suitability for industrial production.

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors

Gerspacher, Marc,Furet, Pascal,Pissot-Soldermann, Carole,Gaul, Christoph,Holzer, Philipp,Vangrevelinghe, Eric,Lang, Marc,Erdmann, Dirk,Radimerski, Thomas,Regnier, Catherine H.,Chene, Patrick,Pover, Alain De,Hofmann, Francesco,Baffert, Fabienne,Buhl, Thomas,Aichholz, Reiner,Blasco, Francesca,Endres, Ralf,Trappe, J?rg,Drueckes, Peter

scheme or table, p. 1724 - 1727 (2010/07/03)

A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure-activity relationship data are also provided.

Derivatives of 5-Thioxylopyranose and Use of Same for Treatment

-

Page/Page column 34, (2009/07/25)

The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.

Process for the preparation of pyridine-2-boronic acid esters

-

Page/Page column 7, (2010/02/09)

Production of 2-pyridineboronic acid ester compounds (I) comprises reacting a 2-halopyridine compound (II) with a metallating reagent to form an organometallic compound (III), reacting (III) with a borate ester compound (IV) to form a complex salt (V), an

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