874186-98-8

Basic information

• Product Name: Pyridine-2-boronic acid pinacol ester
• Synonyms: 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;Pyridine-2-boronic acid pinacol ester;Albb-006131;BP1166pyridine-2boronicacidpinacolester;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(Pyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(2-pyridyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;Pyridine, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen pyridin-2-ylboronate
• CAS NO: 874186-98-8
• Molecular Formula: C11H18BNO3
• Molecular Weight: 223.08
• EINECS: 1533716-785-6
• Mol File: 874186-98-8.mol

Chemical Properties

• Boiling Point: 300.9 °C at 760 mmHg
• Flash Point: 135.8 °C
• Appearance: white to light yellow crystal powde
• Density: 1.03 g/cm³
• Vapor Pressure: 2E-05mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.26±0.19(Predicted)
• CAS DataBase Reference: Pyridine-2-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine-2-boronic acid pinacol ester(874186-98-8)
• EPA Substance Registry System: Pyridine-2-boronic acid pinacol ester(874186-98-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 874186-98-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyridine-2-boronic acid pinacol ester is used as a reactant for the preparation of aminooxazoline azaxanthenes, which are oral β-secretase inhibitors. These inhibitors are crucial in Alzheimer's therapy, as they help regulate the production of amyloid-beta peptides, a key factor in the development of Alzheimer's disease.
Additionally, due to its unique chemical properties and reactivity, Pyridine-2-boronic acid pinacol ester can be employed in the synthesis of other bioactive compounds and pharmaceuticals, contributing to the development of new drugs and therapeutic agents in the pharmaceutical industry.

InChI:InChI=1/C11H16BNO2/c1-10(2,14)11(3,4)16-12(15)9-7-5-6-8-13-9/h5-8,14-15H,1-4H3

Upstream product

• 109-09-1 2-chloropyridine 
• 96649-78-4 2-(cyclohexyloxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 110-86-1 pyridine 
• 109-04-6 2-bromo-pyridine 
• 73183-34-3 bis(pinacol)diborane 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 

Downstream Products

• 879088-40-1 2-(2-chloro-5-nitrophenyl)-pyridine 
• 879088-41-2 4-chloro-3-(pyridin-2-yl)benzeneamine 

Relevant articles and documents

Cationic magnesium hydride [MgH]+ stabilized by an NNNN-type macrocycle

A magnesium hydride cation [(L)MgH]+ supported by a macrocyclic ligand (L = Me4TACD; 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane) has been prepared by partial protonolysis of a mixed amide hydride [(L)MgH2Mg{N(SiMe3)2}2] and shown to undergo a variety of reactions with unsaturated substrates, including pyridine.

Anthracene organic luminescence compound, and preparation method and application thereof

The invention relates to the technical field of organic optoelectronic materials and relates to an anthracene organic luminescence compound, a preparation method thereof and an organic electroluminescence device. The anthracene organic luminescence compound has a structure shown as a formula I: the formula 1 is shown in the description. Compared with other electron transfer layer materials or luminescent layer materials, the novel anthracene organic luminescence compound provided by the invention used as an electron transfer layer material or luminescent layer material of the organic electroluminescence device has the advantage that the luminous efficiency of the device prepared from the material is obviously promoted, and service life is obviously prolonged. The anthracene organic luminescence compound has the advantages of relatively short synthetic route, simple process, easily acquired raw materials, low cost and suitability for industrial production.

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors

A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure-activity relationship data are also provided.

Derivatives of 5-Thioxylopyranose and Use of Same for Treatment

The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.

Process for the preparation of pyridine-2-boronic acid esters

Production of 2-pyridineboronic acid ester compounds (I) comprises reacting a 2-halopyridine compound (II) with a metallating reagent to form an organometallic compound (III), reacting (III) with a borate ester compound (IV) to form a complex salt (V), an