879088-40-1Relevant articles and documents
Preparation method of vimodegil
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, (2020/05/05)
The invention provides a preparation method of vimodegil. 2-chloro-5-nitroacetophenone is used as a raw material; 5-oxo-5-(2-chloro-5-nitrophenyl) n-valeraldehyde is prepared through an addition reaction between 2-chloro-5-nitroacetophenone and acrolein,
A [...] synthesis of intermediates method and application
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Paragraph 0026; 0027; 0028; 0029; 0030; 0031; 0032, (2019/03/28)
The invention relates to a method for synthesizing intermediate [...] and application, which belongs to the field of organic synthesis, in particular to intermediate 2 - (2 - chloro - 5 - nitrophenyl) pyridine (i.e. compound A) preparation process, compri
Preparation method of vismodegib
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Paragraph 0068-0077, (2017/10/07)
The invention relates to a preparation method of vismodegib. The preparation method of the vismodegib comprises the following steps: taking 2-chlorine-5-nitroacetophenone as a starting material, performing 1,4-addition reaction on the 2-chlorine-5-nitroac