874279-86-4

Basic information

• Product Name: 1H-Inden-1-one, 2,2-difluoro-2,3-dihydro-
• Synonyms: 1H-Inden-1-one, 2,2-difluoro-2,3-dihydro-;2,2-Difluoro-2,3-dihydro-1H-inden-1-one
• CAS NO: 874279-86-4
• Molecular Formula: C9H6F2O
• Molecular Weight: 168.14
• Mol File: 874279-86-4.mol

Chemical Properties

• Melting Point: 26-27 °C
• Boiling Point: 210.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Inden-1-one, 2,2-difluoro-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-1-one, 2,2-difluoro-2,3-dihydro-(874279-86-4)
• EPA Substance Registry System: 1H-Inden-1-one, 2,2-difluoro-2,3-dihydro-(874279-86-4)

Safety Data

• Hazardous Substances Data: 874279-86-4(Hazardous Substances Data)

Usage

Bicyclic organic compound

Indenone is a bicyclic aromatic compound consisting of a six-membered benzene ring fused to a five-membered ring.

Fluorinated derivative

The presence of two fluorine atoms in the molecule makes it a fluorinated derivative of indenone, which enhances its reactivity and properties.

Intermediate in production

This chemical is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds, serving as a building block for the synthesis of more complex molecules.

Research and development

1H-Inden-1-one, 2,2-difluoro-2,3-dihydrois used in research and development due to its unique chemical properties and potential applications in various industries.

High reactivity

The difluoro substitution in the molecule makes it highly reactive, allowing it to participate in various chemical reactions for the synthesis of diverse organic compounds.

Upstream product

• 83-33-0 inden-1-one 
• 874279-76-2 N-(2,3-dihydro-1H-inden-1-ylidene)butan-1-amine 
• 31928-64-0 1-trimethylsilyloxy-3H-indene 

Relevant articles and documents

Trifluorinated Tetralins via I(I)/I(III)-Catalysed Ring Expansion: Programming Conformation by [CH2CH2] → [CF2CHF] Isosterism

Saturated, fluorinated carbocycles are emerging as important modules for contemporary drug discovery. To expand the current portfolio, the synthesis of novel trifluorinated tetralins has been achieved. Fluorinated methyleneindanes serve as convenient precursors and undergo efficient difluorinative ring expansion with in situ generated p-TolIF2 (>20 examples, up to >95 %). A range of diverse substituents are tolerated under standard catalysis conditions and this is interrogated by Hammett analysis. X-ray analysis indicates a preference for the CH?F bond to occupy a pseudo-axial orientation, consistent with stabilising σC?H→σC?F* interactions. The replacement of the symmetric [CH2?CH2] motif by [CF2?CHF] removes the conformational degeneracy intrinsic to the parent tetralin scaffold leading to a predictable half-chair. The conformational behavior of this novel structural balance has been investigated by computational analysis and is consistent with stereoelectronic theory.

Bench-Stable Electrophilic Fluorinating Reagents for Highly Selective Mono- and Difluorination of Silyl Enol Ethers

Efficient methods for the synthesis of fluorinated compounds have been intensively studied, recently. Development of practical fluorinating reagents is indispensable for this purpose. Herein, bench-stable electrophilic fluorinating reagents were synthesized as N-fluorobenzenesulfonimide (NFSI) substitutes. Reagents obtained by replacing one of the NFSI sulfonyl groups with an acyl group led to the highly selective monofluorination of silyl enol ethers with suppression of undesired overreaction, that is, difluorination. On the other hand, reagents bearing electron-withdrawing substituents at NFSI benzenesulfonyl groups efficiently facilitated the difluorination of silyl enol ethers under base-free conditions. Thus, both mono- and difluorinated target materials were prepared from the same substrate.

Activation of allylic C-F bonds: Palladium-catalyzed allylic amimation of 3,3-difluoropropenes

(Chemical Equation Present) Lose one, keep one! A wide range of cyclic and acyclic ss-aminofluoroalkenes are prepared by the title reaction. The key fluorinated palladium π-allyl intermediate is generated using a catalytic allylic C-F bond activation.

Efficient synthesis of α,α-difluoro ketones using selectfluor F-TEDA-BF4

Selective and efficient synthesis of α,α-difluoro ketones was achieved following a protocol which includes the transformation of α-methylene ketones to the corresponding n-butylimine derivatives and their further treatment with Selectfluor F-TEDA-BF4