874379-35-8

Basic information

• Product Name: 1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE
• Synonyms: 1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE
• CAS NO: 874379-35-8
• Molecular Formula: C₉H₇NO
• Molecular Weight: 145.15798
• Mol File: 874379-35-8.mol

Chemical Properties

• Boiling Point: 261.3 °C at 760 mmHg
• Flash Point: 118.7 °C
• Appearance: /
• CAS DataBase Reference: 1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE(874379-35-8)
• EPA Substance Registry System: 1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE(874379-35-8)

Safety Data

• Hazardous Substances Data: 874379-35-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(6-Ethynyl-pyridin-2-yl)-ethanone is used as a versatile intermediate for the synthesis of heterocyclic compounds, leveraging its ethynyl group for coupling reactions that facilitate the creation of a variety of organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-(6-Ethynyl-pyridin-2-yl)-ethanone serves as a key component in the development of new drugs, capitalizing on its reactivity and structural attributes to produce compounds with potential therapeutic applications.
Used in Agrochemical Production:
1-(6-ETHYNYL-PYRIDIN-2-YL)-ETHANONE is also utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of products designed to enhance crop protection and yield.
Used in the Development of New Materials:
1-(6-Ethynyl-pyridin-2-yl)-ethanone is employed as a building block in material science, where its unique properties are harnessed to engineer innovative materials with specific applications.
Used in the Production of Fine Chemicals:
Its role in the production of fine chemicals underscores its importance in creating high-purity substances used in various specialized applications, including research and industry.
Used in Medicinal Chemistry:
Due to its structural properties and ability to interact with biological targets, 1-(6-Ethynyl-pyridin-2-yl)-ethanone has potential applications in medicinal chemistry, where it may contribute to the discovery and design of new therapeutic agents.

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 49669-13-8 1-(6-bromopyridin-2-yl)-ethanone 
• 874379-34-7 1-(6-((trimethylsilyl)ethynyl)pyridin-2-yl)ethan-1-one 
• 874379-36-9 2-acetyl-6-(3-methylbutyn-1-yl)pyridine 

Downstream Products

• 874379-29-0 1,2-di(6-acetylpyrid-2-yl)ethyne 

Relevant articles and documents

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

HYDRAZNE DERIVATIVES FOR THE TREATMENT OF CANCER

The invention provides compounds of formula (I): and salts thereof, wherein ring A, R2, HET, X, n, and R3 have any of the meanings described in the specification, as well as compositions comprising such compounds and salts, and methods for treating cancer using such compounds and salts.

Synthetic approaches to polypyridyl bridging ligands with proximal multidentate binding sites

A series of 12 bridging ligands was prepared. These ligands include a central linker appended to two 1,8-naphthyrid-2-yl or two 1,10-phenanthrolin-2- yl units. The linkers include pyridazin-3,6-diyl, 1,8-naphthyrid-2,7-diyl, 2,2′-bipyrid-6,6′-diyl, 1,10-phenanthrolin-2,9-diyl, 1,2-di(2′-pyrid-6′-yl)ethyne, and 3,6-di(2′-pyrid-6′-yl) pyridazine. The ligands were synthesized from the diacetyl derivative of the central linker by a Friedlaender condensation with either 2-aminonicotinaldehyde or 8-amino-7-quinolinecarbaldehyde. The precursor diacetyl derivatives were, in turn, prepared by pathways involving Stille and Sonogashira couplings. Examination of the electronic absorption spectra of the bridging ligands shows the strongest correlation to be between pairs of ligands having the same central linker. Complexation studies will follow.