874479-16-0

Basic information

• Product Name: (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile
• Synonyms: (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile;(2Z)-3-Chloro-3-(4-methoxyphenyl)-2-propenenitrile
• CAS NO: 874479-16-0
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.62962
• Mol File: 874479-16-0.mol

Chemical Properties

• Boiling Point: 335℃
• Flash Point: 157℃
• Appearance: /
• Density: 1.191
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile(874479-16-0)
• EPA Substance Registry System: (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile(874479-16-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 874479-16-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile is used as an intermediate in the synthesis of various pharmaceuticals for its highly reactive nature, enabling the creation of a wide range of medicinal compounds.
Used in Agrochemical Industry:
(Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile is used as an intermediate in the synthesis of various agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Organic Compounds Synthesis:
(Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile is used as a key intermediate in the synthesis of other organic compounds, owing to its reactivity and ability to form a variety of chemical structures.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 14063-79-7 (Z)-3-chloro-3-(4-methoxyphenyl)acrylaldehyde 

Downstream Products

• 943252-41-3 3-amino-5-(4-methoxyphenyl)-2-thiophenecarbonitrile 
• 1042166-55-1 C₁₉H₁₅N₃O₂ 
• 1042166-58-4 C₂₀H₁₇N₃O₃ 
• 1042166-52-8 C₁₄H₁₃N₃O₂ 
• 1021444-01-8 3-amino-5-(4-methoxyphenyl)-2-nitroselenophene 
• 1021443-93-5 3-amino-5-(4-methoxyphenyl)-2-nitrothiophene 
• 474843-51-1 3-(ethoxyoxalyl-amino)-5-(4-methoxy-phenyl)-thiophene-2-carboxylic acid methyl ester 
• 943252-47-9 9-amino-2-(4-methoxyphenyl)-6,7-dihydrothieno[3,2-b]quinolin-8(5H)-one 
• 943252-45-7 5-(4-methoxyphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile 
• 37572-23-9 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of thiophene analogues of the tacrine series

3-Amino-2-cyanothiophenes condensed with cyclanones and afforded analogues of Velnacrine in two or three steps. Condensation under Friedlander's conditions gave tacrine analogues in one step. Georg Thieme Verlag Stuttgart.

Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors

2-(3′,4′,5′-Trimethoxybenzoyl)-3-amino-5-aryl/heteroaryl thiophene derivatives were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. SARs were elucidated with various substitutions on

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B

Reversible phosphorylation and dephosphorylation of key proteins on tyrosine residues are important parts of intracellular signaling triggered by hormones and other agents. Recent knock-out studies in mice have identified PTP1B as a potential target for t