(Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile

Base Information

• Chemical Name: (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile
• CAS No.: 874479-16-0
• Molecular Formula: C10H8 Cl N O
• Molecular Weight: 193.63000
• Mol file: 874479-16-0.mol

Synonyms:(Z)-3-Chloro-3-(4-methoxyphenyl)acrylonitrile;(2Z)-3-chloro-3-(4-methoxyphenyl)prop-2-enenitrile;HknH`ItHcHhhddbaVdHLhABH;(2Z)-3-Chloro-3-(4-methoxyphenyl)-2-propenenitrile;

Chemical Property of (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile

Chemical Property:

• Boiling Point: 335℃
• Flash Point: 157℃
• PSA: 33.02000
• Density: 1.191
• LogP: 2.79848
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(Z)-3-Chloro-3-(4-methoxyphenyl)acrylonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile

There total 4 articles about (Z)-3-chloro-3-(4-methoxyphenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-(4-methoxyphenyl)ethanone (100-06-1) → (Z)-3-chloro-3-(4-methoxyphenyl)-2-propenenitrile (874479-16-0)

Guidance literature:

N,N-dimethyl-formamide; 1-(4-methoxyphenyl)ethanone; With trichlorophosphate; at 25 - 50 ℃;

With hydroxylamine hydrochloride; at 25 - 50 ℃;

DOI:10.1021/jm0209026

Reference yield:

(Z)-3-chloro-3-(4-methoxyphenyl)acrylaldehyde (14063-79-7) → (Z)-3-chloro-3-(4-methoxyphenyl)-2-propenenitrile (874479-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine chloride / ethanol

2: Ac₂O

With acetic anhydride; In ethanol;

DOI:10.1055/s-2007-965944

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → (Z)-3-chloro-3-(4-methoxyphenyl)-2-propenenitrile (874479-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃ / 5 h / 60 °C

2: hydroxylamine chloride / ethanol

3: Ac₂O

With acetic anhydride; trichlorophosphate; In ethanol;

DOI:10.1055/s-2007-965944

upstream raw materials:

N,N-dimethyl-formamide

1-(4-methoxyphenyl)ethanone

(Z)-3-chloro-3-(4-methoxyphenyl)acrylaldehyde

Downstream raw materials:

3-amino-5-(4-methoxyphenyl)-2-thiophenecarbonitrile

3-(ethoxyoxalyl-amino)-5-(4-methoxy-phenyl)-thiophene-2-carboxylic acid methyl ester

C₁₄H₁₃N₃O₂

C₂₀H₁₇N₃O₃