Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors
This letter describes the discovery and SAR optimization of tetrazoyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m exhibited robust HDL-c increase in hCETP/hApoA1 double transgenic model and favorable pharmacokinetic properties.
Escribano, Ana,Mateo, Ana I.,Martin De La Nava, Eva M.,Mayhugh, Daniel R.,Cockerham, Sandra L.,Beyer, Thomas P.,Schmidt, Robert J.,Cao, Guoqing,Zhang, Youyan,Jones, Timothy M.,Borel, Anthony G.,Sweetana, Stephanie A.,Cannady, Ellen A.,Mantlo, Nathan B.
p. 3671 - 3675
(2012/07/16)
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