- A hexafluoropropylene directly to the aryl borate method of oxidation heptafluoro isopropylation
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The invention relates to a method for directly oxidizing arylboronic acid into heptafluoroisopropyl by utilizing hexafluoropropylene. The method comprises the following steps that silver fluoride is used as a fluorine source, under the effect of copper salt, the hexafluoropropylene and the arylboronic acid can be converted into a series of compounds containing heptafluoroisopropyl in organic solvents at the room temperature, and the reaction is also applicable to alkenylboronic acids. The method has the advantage that a series of compounds containing the heptafluoroisopropyl are synthesized through one-step reaction at high selectivity.
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Paragraph 0060-0066; 0111; 0112; 0113; 0114
(2016/10/20)
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- Direct heptafluoroisopropylation of arylboronic acids via hexafluoropropene (HFP)
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A novel and straightforward strategy for heptafluoroisopropylation of arylboronic acids at room temperature has been developed. This method, directly using commercial available hexafluoropropene (HFP) as the starting material, provides a new way to synthesize a variety of synthetically useful heptafluoroisopropylated arenes.
- Li, Yajun,Wang, Xiaojun,Guo, Yuwei,Zhu, Zhentong,Wu, Yongming,Gong, Yuefa
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supporting information
p. 796 - 799
(2016/01/12)
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- Heteroaryl and benzyl amide compounds
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Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.
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Page/Page column 9
(2010/11/28)
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