875306-42-6Relevant articles and documents
A hexafluoropropylene directly to the aryl borate method of oxidation heptafluoro isopropylation
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Paragraph 0060-0066; 0111; 0112; 0113; 0114, (2016/10/20)
The invention relates to a method for directly oxidizing arylboronic acid into heptafluoroisopropyl by utilizing hexafluoropropylene. The method comprises the following steps that silver fluoride is used as a fluorine source, under the effect of copper salt, the hexafluoropropylene and the arylboronic acid can be converted into a series of compounds containing heptafluoroisopropyl in organic solvents at the room temperature, and the reaction is also applicable to alkenylboronic acids. The method has the advantage that a series of compounds containing the heptafluoroisopropyl are synthesized through one-step reaction at high selectivity.
Heteroaryl and benzyl amide compounds
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Page/Page column 9, (2010/11/28)
Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.