87597-27-1

Basic information

• Product Name: Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester
• Synonyms: Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester;Ethyl 5-broMoiMidazo[1,2-a]pyrazine-2-carboxylate;5-Bromo-imidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester;methyl 5-bromoimidazo[1,2-a]pyrazine-2-carboxylate
• CAS NO: 87597-27-1
• Molecular Formula: C₉H₈BrN₃O₂
• Molecular Weight: 270.085
• Mol File: 87597-27-1.mol

Chemical Properties

• Appearance: /
• Density: 1.72g/cm³
• Refractive Index: 1.673
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester(87597-27-1)
• EPA Substance Registry System: Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester(87597-27-1)

Safety Data

• Hazardous Substances Data: 87597-27-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester is used as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile reactions and the formation of a wide range of chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester is used as a starting material or building block in the development of new drugs and therapeutics. Its potential applications may include the synthesis of novel compounds with medicinal properties, contributing to the advancement of treatments for various diseases and conditions.
Safety Considerations:
Due to its potential reactivity and toxicity, it is crucial to handle and use Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5-bromo-, ethyl ester with caution. Adherence to proper safety protocols and guidelines is essential to minimize risks and ensure the safe application of this compound in research and industrial settings.

InChI:InChI=1/C9H8BrN3O2/c1-2-15-9(14)6-5-13-7(10)3-11-4-8(13)12-6/h3-5H,2H2,1H3

Upstream product

• 77112-52-8 ethyl imidazo[1,2-a]pyrazine-2-carboxylate 
• 65868-37-3 ethyl 2-oxo-3-chloropropionate 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 870244-18-1 5-biphenyl-4-ylmethyl-imidazol[1,2-a]pyrazine-2-carboxylic acid 

Relevant articles and documents

KINASE INHIBITORS AS THERAPEUTIC AGENTS

A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.