77112-52-8

Basic information

• Product Name: ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE
• Synonyms: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE;WCIUYUMPQYSUSD-GBCQHVBFSA-N
• CAS NO: 77112-52-8
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.19
• Mol File: 77112-52-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 175-177 °C(Solv: ethanol (64-17-5))
• Appearance: /
• Density: 1.332 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.78±0.30(Predicted)
• CAS DataBase Reference: ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE(77112-52-8)
• EPA Substance Registry System: ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE(77112-52-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77112-52-8(Hazardous Substances Data)

Usage

General Description

Ethyl imidazo[1,2-a]pyrazine-2-carboxylate is a chemical compound with the molecular formula C10H10N2O2. It is a carboxylate ester, and it is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It can act as a building block for the preparation of diverse imidazo[1,2-a]pyrazine derivatives, which have various biological activities, including antiviral, anticancer, and anti-inflammatory properties. ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE is also used as a flavor and fragrance ingredient in the food and cosmetic industries, imparting a unique aroma to products. It is important to handle and store ethyl imidazo[1,2-a]pyrazine-2-carboxylate with caution, as it can be hazardous if not properly managed.

Upstream product

• 64-17-5 ethanol 
• 77112-53-9 imidazo <1,2-a>pyrazine-2-carboxylic acid 
• 5049-61-6 2-Aminopyrazine 
• 92234-23-6 ethyl 3-bromo-2-hydroxy propionate 
• 65868-37-3 ethyl 2-oxo-3-chloropropionate 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 77124-59-5 imidazo <1,2-a>pyrazine-2-carboxamide 
• 91476-82-3 tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 d'ethyle 
• 77112-53-9 imidazo <1,2-a>pyrazine-2-carboxylic acid 
• 87597-36-2 Imidazo[1,2-a]pyrazine-2-carboxylic acid hydrazide 
• 87597-27-1 5-bromo-imidazol[1,2-a]pyrazine-2-carboxylic acid ethyl ester 
• 870244-18-1 5-biphenyl-4-ylmethyl-imidazol[1,2-a]pyrazine-2-carboxylic acid 
• 1174069-07-8 ethyl 7-(tert-butoxycarbonyl)-3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate 
• 1053656-22-6 7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 
• 723286-62-2 ethyl 7-[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate 
• 1250999-20-2 2-bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 
• 1250996-70-3 tert-butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate 
• 1608503-42-9 phenyl 7-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate 
• 1608503-36-1 C₂₅H₂₁ClF₂N₆O 

Relevant articles and documents

ROCK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

The invention relates to a ROCK inhibitor represented by formula (I), its preparation method and its use. The ROCK inhibitor has excellent ROCK inhibition activity, in particular good selective inhibition on ROCK2 kinase, has good safety and metabolic stability, and has high bioavailability. The process of preparing the ROCK inhibitor is simple, and the ROCK inhibitor is easy to purify, and therefore offers good prospects for application.

HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS

The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, Parkinson's disease and the like.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.