876317-19-0

Basic information

• Product Name: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: 4-OXOPYRROLIDINE-2-CARBOXYLIC ACID, N-BOC PROTECTED;4-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;4-Oxopyrrolidine-2-carboxylic acid, N-BOC protected 97%;BOC- 4-OXOPYRROLIDINE-2-CARBOXYLIC ACID;(2S)-1-TERT-BUTYL HYDROGEN 4-OXOPYRROLIDINE-1,2-DICARBOXYLATE
• CAS NO: 876317-19-0
• Molecular Formula: C₁₀H₁₅NO₅
• Molecular Weight: 229.23
• Mol File: 876317-19-0.mol

Chemical Properties

• Melting Point: 155 °C
• Boiling Point: 390.756°C at 760 mmHg
• Flash Point: 190.123°C
• Appearance: /
• Density: 1.305g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: 2-8°C
• PKA: 3.85±0.20(Predicted)
• CAS DataBase Reference: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID(876317-19-0)
• EPA Substance Registry System: 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID(876317-19-0)

Safety Data

• Hazardous Substances Data: 876317-19-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID is used as a protecting group for the amine group in organic synthesis, ensuring the selective protection of the amine functionality during the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID is used as an important intermediate for the synthesis of various drugs. Its unique chemical properties allow for the development of new pharmaceutical compounds with specific therapeutic effects.
Used in Agrochemical Production:
Similarly, in the agrochemical industry, 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID is utilized as a key intermediate for the synthesis of agrochemicals, contributing to the development of effective crop protection products and other agricultural applications.

InChI:InChI=1/C10H15NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h7H,4-5H2,1-3H3,(H,13,14)

Upstream product

• 40350-82-1 1-(t-butoxycarbonyl)-4-hydroxyproline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51-35-4 3-hydroxy-dl-proline 

Downstream Products

• 362706-26-1 methyl 1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2carboxylate 
• 1000313-00-7 1-(tert-butyl) 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate 
• 1000313-01-8 1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid 
• 1330763-18-2 5-tert-butoxycarbonyl-2-oxa-5-azabicyclo[2.2.1]heptane-1-carboxylic acid 
• 1199793-53-7 1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate 
• 1199793-52-6 (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid 
• 5763-61-1 3,4-dimethoxybenzylamine 
• 102195-80-2 (S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate 
• 364072-21-9 (2S)-N₂-(2,1,3-benzothiadiazol-4-yl)-N₁-(3,5-dichlorophenyl)-4-oxo-1,2-pyrrolidinedicarboxamide 
• 767-64-6 4-Amino-2,1,3-benzothiadiazole 
• 364073-42-7 (2S)-N₁-(3,5-dichlorophenyl)-N₂-(3,4-dimethoxybenzyl)-4-oxo-1,2-pyrrolidinedicarboxamide 
• 364075-47-8 (2S)-N-(1,3-benzodioxol-5-ylmethyl)-4-oxo-2-pyrrolidinecarboxamide 

Relevant articles and documents

5-tert-butyloxycarbonyl-2-oxa-5-azabicyclo[2.2.1]heptane-1-carboxylic acid synthesis method

The present invention relates to a 5-tert-butyloxycarbonyl-2-oxa-5-azabicyclo[2.2.1]heptane-1-carboxylic acid synthesis method. In the prior art, the suitable industrial synthesis method does not exist. A purpose of the present invention is mainly to solve the technical problem in the prior art. The synthesis method comprises six steps, and specifically comprises that a compound 1 and Boc anhydride react under an alkaline condition to obtain a compound 2, the compound 2 is oxidized into a compound 3 by using a 2,2,6,6-tetramethyl piperidine oxide, the compound 3 reacts with a Grignard reagent to obtain a compound 4, the carboxylic acid 4 is reduced with lithium aluminum hydride to obtain a compound 5, the compound 5 reacts with n-butyl lithium and p-tosyl chloride in two stages to obtain a compound 6, and the compound 6 is oxidized with sodium periodate to obtain a final compound 7. The reaction formula is defined in the specification.