Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents
The lead optimization of a series of N-substituted benzimidazole CXCR4 antagonists is described. Side chain modifications and stereochemical optimization led to substantial improvements in potency and protein shift to afford compounds with low nanomolar a
Miller, John F.,Turner, Elizabeth M.,Gudmundsson, Kristjan S.,Jenkinson, Stephen,Spaltenstein, Andrew,Thomson, Michael,Wheelan, Pat
The present invention provides compounds of Formula (I) comprising: including salts, solvates, and physiologically functional derivatives thereof, pharmaceutical formulations containing them, processes for their preparation, and methods of treatment using them.
-
Page/Page column 87
(2008/06/13)
CHEMICAL COMPOUNDS
The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.
-
Page/Page column 115; 116
(2010/10/20)
More Articles about upstream products of 876590-07-7