- AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17
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The present invention relates to a compound according to formula I (I) and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
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Page/Page column 110
(2020/07/14)
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- Experimental Demonstration of a Sizeable Nonclassical CH···G Hydrogen Bond in Cyclohexane Derivatives: Stabilization of an Axial Cyano Group
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Base-catalyzed equilibration of anancomeric cyanocyclohexanes demonstrates that replacement of cis-3,5-dimethyl holding groups with electron-withdrawing CF3 groups dramatically increases the proportion of the axial cyano isomer present at equilibrium. The CF3 groups exert an effect on the conformational energy of the cyano group worth about 0.6 kcal/mol. A nonclassical hydrogen bond between the axial CN group and the syn-axial hydrogens is a major contributor to the axial stability of the group.
- Lambert, Kyle M.,Stempel, Zachary D.,Wiberg, Kenneth B.,Bailey, William F.
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supporting information
p. 6408 - 6411
(2017/12/08)
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- Enantio- and Regioselective Ir-Catalyzed Hydrogenation of Di- and Trisubstituted Cycloalkenes
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A number of cyclic olefins were prepared and evaluated for the asymmetric hydrogenation reaction using novel N,P-ligated iridium imidazole-based catalysts (Crabtree type). The diversity of these cyclic olefins spanned those having little functionality to
- Peters, Byron K.,Liu, Jianguo,Margarita, Cristiana,Rabten, Wangchuk,Kerdphon, Sutthichat,Orebom, Alexander,Morsch, Thomas,Andersson, Pher G.
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supporting information
p. 11930 - 11935
(2016/10/07)
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- Pd-Catalyzed Regio- and Stereo-selective Carboxylation of Cycloalkanes with CO
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The reactions of cycloalkanes with CO via the C-H bond activation by Pd(OAc)2 catalyst have been found to proceed regio- and stereo-selectively to give corresponding carboxylic acids.The reactivity of C-H bonds of cycloalkanes decreases in the order: tert- > sec- > prim-carbon, and the stereochemistry of the substitutents on the main products is all equatorial.
- Satoh, Ko-ichi,Watanabe, Jun,Takaki, Ken,Fujiwara, Yuzo
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p. 1433 - 1436
(2007/10/02)
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