876918-30-8

Basic information

• Product Name: 5-BroMo-2-(piperidin-1-yl)benzonitrile
• Synonyms: 5-BroMo-2-(piperidin-1-yl)benzonitrile
• CAS NO: 876918-30-8
• Molecular Formula: C₁₂H₁₃BrN₂
• Molecular Weight: 265.14902
• Mol File: 876918-30-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BroMo-2-(piperidin-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-2-(piperidin-1-yl)benzonitrile(876918-30-8)
• EPA Substance Registry System: 5-BroMo-2-(piperidin-1-yl)benzonitrile(876918-30-8)

Safety Data

• Hazardous Substances Data: 876918-30-8(Hazardous Substances Data)

Upstream product

• 34595-33-0 5-amino-2-(piperidin-1-yl)benzonitrile 
• 81538-01-4 2-(5-bromo-2-methoxyphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 110-89-4 piperidine 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 

Relevant articles and documents

Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines

A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, ethyl cyanoformate or allylic bromides (39 examples, 62–99 % yield) is reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50 °C, 4 h) provided the corresponding nitriles (36 examples, 73–99 % yield). Conversions of these nitriles to valuable heterocycles are reported, and a tentative mechanism is proposed.

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