81538-01-4Relevant academic research and scientific papers
Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines
Hess,Guelen,Alandini,Mourati,Guersoy,Knochel
supporting information, (2021/12/06)
A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, ethyl cyanoformate or allylic bromides (39 examples, 62–99 % yield) is reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50 °C, 4 h) provided the corresponding nitriles (36 examples, 73–99 % yield). Conversions of these nitriles to valuable heterocycles are reported, and a tentative mechanism is proposed.
Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists
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, (2008/06/13)
This invention relates to substituted and unsubstituted ???(aryl- and heteroaryl-) alkyl-, alkyloxy-, alkylthio-, oxo-, thio-, and alkylamino!- heteroaryl and aryl!- alkylamino-, aminoalkyl-, alkyloxy-, and alkylthio!- aryl and heteroaryl compounds of the formula STR1 and pharmaceutically acceptable salts thereof, which are useful as antagonists of the pain enhancing effects of E-type prostaglandins, to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods for treating pain comprising the administration of such compounds.
Dibenz[c,e]azepines
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, (2008/06/13)
7-Aryl-5H-dibenz[c,e]azepines, e.g., those of the formula STR1 Ar'=phenyl, furyl, thienyl, pyridyl or phenyl subst. by alkyl, OH, alkoxy, halo or CF3 ; R'=halo or CF3 N-oxides or salts thereof are anxiolytic agents.
