877060-47-4

Basic information

• Product Name: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE
• Synonyms: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE;3-IODO-5-AZAINDOLE
• CAS NO: 877060-47-4
• Molecular Formula: C₇H₅IN₂
• Molecular Weight: 244.03
• Product Categories: Heterocycle-Pyridine series
• Mol File: 877060-47-4.mol

Chemical Properties

• Melting Point: 178-179℃
• Boiling Point: 380.547°C at 760 mmHg
• Flash Point: 183.948°C
• Appearance: /
• Density: 2.082
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.788
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE(877060-47-4)
• EPA Substance Registry System: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE(877060-47-4)

Safety Data

• Hazardous Substances Data: 877060-47-4(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
3-IODO-1H-PYRROLO[3,2-C]PYRIDINE is used as a pharmaceutical precursor for the development of drugs, leveraging its unique structure and reactivity to create novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE is utilized as a key intermediate, contributing to the construction of complex organic molecules for various applications, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
3-IODO-1H-PYRROLO[3,2-C]PYRIDINE serves as a valuable compound in research settings, where its properties are explored for potential applications in new drug discovery and the advancement of chemical synthesis techniques.

InChI:InChI=1/C7H5IN2/c8-6-4-10-7-1-2-9-3-5(6)7/h1-4,10H

Upstream product

• 271-34-1 5-azaindole 

Downstream Products

• 1428226-76-9 C₁₇H₁₂ClN₅ 
• 1428226-75-8 C₁₇H₁₂ClN₅ 
• 1428226-74-7 C₁₇H₁₂ClN₅ 
• 1428226-68-9 C₁₇H₁₃N₅ 
• 1316228-30-4 C₂₁H₂₁N₅O₂ 
• 1316228-54-2 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[3,2-c]pyridine 
• 877060-60-1 1-tert-butyloxycarbonyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrrolo[3,2-c]pyridine 
• 877060-48-5 tert-butyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 

Relevant articles and documents

BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

THERAPEUTIC INHIBITORY COMPOUNDS

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

N-substituted azaindoles as potent inhibitors of Cdc7 kinase

Cdc7 kinase is responsible for the initiation and regulation of DNA replication and has been proposed as a target for cancer therapy. We have identified a class of Cdc7 inhibitors based on a substituted indole core. Synthesis of focused indole and azaindole analogs yielded potent and selective 5-azaindole Cdc7 inhibitors with improved intrinsic metabolic stability (ie 36). In parallel, quantum mechanical conformational analysis helped to rationalize SAR observations, led to a proposal of the preferred binding conformation in the absence of co-crystallography data, and allowed the design of 7-azaindole 37 as a second lead in this series.

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly di

[4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF

The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically the present invention relates to compounds that having a tryptase inhibition activity and the intermediates thereof, pharmaceutical compositions comprising such compounds, and a method of treating subjects suffering from a condition disease or disorder that can be ameliorated by the administration of an inhibitor of tryptase including but not limited to for example asthma and other inflammatory diseases including age-related macular degeneration.

Versatile and convenient methods for the synthesis of C-2 and C-3 functionalised 5-azaindoles

Functionalisation at C-2 and C-3 of N-protected-5-azaindole leads to a variety of very useful new substituted 5-azaindole derivatives in fair to good yields. Georg Thieme Verlag Stuttgart.