877060-48-5

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 3-iodo-, 1,1-dimethylethyl ester is used as a synthetic intermediate for the development of new pharmaceuticals. Its unique structure and reactivity make it a valuable building block in the synthesis of various medicinal compounds, potentially leading to the creation of novel drugs with improved therapeutic profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Pyrrolo[3,2-c]pyridine-1-carboxylicacid, 3-iodo-, 1,1-dimethylethyl ester serves as a synthetic intermediate for the production of agrochemicals. Its application in this field is crucial for the development of new pesticides, herbicides, and other agricultural chemicals that can enhance crop protection and yield.
Used in Research and Development:
1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 3-iodo-, 1,1-dimethylethyl ester is utilized as a building block in the synthesis of various organic compounds in research and development settings. Its unique chemical properties allow for the exploration of new chemical reactions and the creation of innovative organic molecules with potential applications across different industries.

Upstream product

• 271-34-1 5-azaindole 
• 877060-47-4 3-iodo-1H-pyrrolo[3,2-c]pyridine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 877060-55-4 3-formyl-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester 
• 1316228-30-4 C₂₁H₂₁N₅O₂ 
• 1316228-54-2 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[3,2-c]pyridine 
• 1050372-86-5 phenyl[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)pyrimidin-2-yl]-amine 
• 877060-60-1 1-tert-butyloxycarbonyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrrolo[3,2-c]pyridine 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly di

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.

Versatile and convenient methods for the synthesis of C-2 and C-3 functionalised 5-azaindoles

Functionalisation at C-2 and C-3 of N-protected-5-azaindole leads to a variety of very useful new substituted 5-azaindole derivatives in fair to good yields. Georg Thieme Verlag Stuttgart.