An unexpected result in the condensation of 2-amino-6-bromo- pyridine with ethyl 4-chloroacetoacetate: Four dihalo-substituted pyrido[1,2-a]pyrimidin-4-ones as reaction products
We report here the condensation of 2-amino-6-bromopyridine with ethyl 4-chloroacetoacetate in polyphosphoric acid. In this reaction, a mixture of the four possible dihalo-4H-pyrido[1,2- a]pyrimidin-4-ones 1-4 was obtained.
Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones investigated as antimicrobial agents
Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones and assay of their antibacterial and antifungal activity are reported. Compounds 3a-e,g were prepared by reaction of substituted 2-chloromethyl-4H-pyrido[1,2-a]pyrimidin-4-ones 2a-c with suitable amines. These compounds and the previously obtained analogues 5a-o and 6a,b have been tested for their antimicrobial activity. All tested compounds were devoid of antimicrobial activity.
Ferrarini,Mori,Armani,Rossi
p. 69 - 72
(2007/10/02)
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