87779-02-0

Basic information

• Product Name: 2-chloromethyl-6-chloro-4H-pyridopyrimidin-4-one
• Synonyms: 2-chloromethyl-6-chloro-4H-pyridopyrimidin-4-one
• CAS NO: 87779-02-0
• Molecular Formula: C₉H₆Cl₂N₂O
• Molecular Weight: 229.06274
• Mol File: 87779-02-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloromethyl-6-chloro-4H-pyridopyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloromethyl-6-chloro-4H-pyridopyrimidin-4-one(87779-02-0)
• EPA Substance Registry System: 2-chloromethyl-6-chloro-4H-pyridopyrimidin-4-one(87779-02-0)

Safety Data

• Hazardous Substances Data: 87779-02-0(Hazardous Substances Data)

Upstream product

• 45644-21-1 6-chloropyridin-2-amine 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 19798-81-3 2-Amino-6-bromopyridine 

Relevant articles and documents

An unexpected result in the condensation of 2-amino-6-bromo- pyridine with ethyl 4-chloroacetoacetate: Four dihalo-substituted pyrido[1,2-a]pyrimidin-4-ones as reaction products

We report here the condensation of 2-amino-6-bromopyridine with ethyl 4-chloroacetoacetate in polyphosphoric acid. In this reaction, a mixture of the four possible dihalo-4H-pyrido[1,2- a]pyrimidin-4-ones 1-4 was obtained.

Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones investigated as antimicrobial agents

Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones and assay of their antibacterial and antifungal activity are reported. Compounds 3a-e,g were prepared by reaction of substituted 2-chloromethyl-4H-pyrido[1,2-a]pyrimidin-4-ones 2a-c with suitable amines. These compounds and the previously obtained analogues 5a-o and 6a,b have been tested for their antimicrobial activity. All tested compounds were devoid of antimicrobial activity.