879553-92-1Relevant articles and documents
Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread
Garcia, Manon,Hoffer, Laurent,Leblanc, Rapha?l,Benmansour, Fatiha,Feracci, Mikael,Derviaux, Carine,Egea-Jimenez, Antonio Luis,Roche, Philippe,Zimmermann, Pascale,Morelli, Xavier,Barral, Karine
, (2021/07/09)
Syntenin stimulates exosome production and its expression is upregulated in many cancers and implicated in the spread of metastatic tumor. These effects are supported by syntenin PDZ domains interacting with syndecans. We therefore aimed to develop, throu
Impact of stereochemistry on ligand binding: X-ray crystallographic analysis of an epoxide-based HIV protease inhibitor
Benedetti, Fabio,Berti, Federico,Campaner, Pietro,Fanfoni, Lidia,Demitri, Nicola,Olajuyigbe, Folasade M.,De March, Matteo,Geremia, Silvano
supporting information, p. 968 - 972 (2014/12/10)
A new pseudopeptide epoxide inhibitor, designed for irreversible binding to HIV protease (HIV-PR), has been synthesized and characterized in solution and in the solid state. However, the crystal structure of the complex obtained by inhibitor-enzyme cocrys
