- Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918
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In our ongoing efforts to develop CGRP receptor antagonists for the treatment of migraine, we aimed to improve upon telecagepant by targeting a compound with a lower projected clinical dose. Imidazoazepanes were identified as potent caprolactam replacemen
- Paone, Daniel V.,Nguyen, Diem N.,Shaw, Anthony W.,Burgey, Christopher S.,Potteiger, Craig M.,Deng, James Z.,Mosser, Scott D.,Salvatore, Christopher A.,Yu, Sean,Roller, Shane,Kane, Stefanie A.,Selnick, Harold G.,Vacca, Joseph P.,Williams, Theresa M.
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scheme or table
p. 2683 - 2686
(2011/06/20)
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- CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS
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Compounds of formula I: I wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as mi
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Page/Page column 52-53
(2009/01/24)
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