- Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening
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Ataluren, also known as PTC124, is a 5-(fluorophenyl)-1,2,4-oxadiazolyl-benzoic acid suggested to suppress nonsense mutations by readthrough of premature stop codons in the mRNA. Potential interaction of PTC124 with mRNA has been recently studied by molec
- Pibiri, Ivana,Lentini, Laura,Tutone, Marco,Melfi, Raffaella,Pace, Andrea,Di Leonardo, Aldo
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p. 429 - 435
(2016/07/15)
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- The accelerated development of an optimized synthesis of 1,2,4-oxadiazoles: Application of microwave irradiation and statistical design of experiments
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Herein, we report the development of an optimized microwave-assisted synthesis of 1,2,4-oxadiazoles. The chemistry development process was significantly accelerated by employing a statistical software package (MODDE 6.0) to guide in the optimization of the reaction conditions. The resulting optimized reaction conditions were then utilized in the synthesis of a focused library of 1,2,4-oxadiazoles.
- Evans, Marc D.,Ring, Jessica,Schoen, Adam,Bell, Andrew,Edwards, Paul,Berthelot, Didier,Nicewonger, Robb,Baldino, Carmen M.
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p. 9337 - 9341
(2007/10/03)
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- Synthesis of 5-aryl-3-(4-pyridyl)-1,2,4-oxadiazoles
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The title oxadiazoles were formed in the reaction of N-(4-pyridylmethyl)arylamides with nitrosyl chloride in low yields.
- Brana,Castellano,Yunta
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p. 1403 - 1405
(2007/10/02)
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