Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl) pyridine template
We have developed a series of novel potent ((pyridin-4-yl)ethyl)pyridine derivatives active against kinases VEGFR-1 and -2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase selectivity could be controlled by varying the
Kiselyov, Alexander S.,Semenova, Marina,Semenov, Victor V.,Milligan, Daniel
p. 1913 - 1919
(2007/10/03)
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