- COMPOUNDS AND METHOD OF USE
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This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.
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Paragraph 1038
(2019/09/06)
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- Bismuth(III)-Promoted Acetylation of Thioethers into Thioacetates
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The thioacetate group is extensively employed as an anchoring group for attachment of molecules onto gold surfaces or between electrodes in molecular electronics. On account of its ready hydrolysis, it is often incorporated in the last step of a synthetic
- Jevric, Martyn,Petersen, Anne Ugleholdt,Mans?, Mads,Madsen, Anders,Nielsen, Mogens Br?ndsted
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p. 4675 - 4688
(2015/08/03)
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- Copper-free sonogashira coupling reaction using a trans-spanning 1,2-Bis(2-thienylethynyl)benzene ligand
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Novel copper-free Sonogashira coupling reaction of aryl halides with terminal acetylenes proceeded in the presence of 1,2-bis(2-thienylethynyl) benzene (1) as a trans-bidentatable ligand.
- Atobe, Shingo,Sonoda, Motohiro,Suzuki, Yuki,Shinohara, Hiroyuki,Yamamoto, Takuya,Ogawa, Akiya
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supporting information; experimental part
p. 980 - 982
(2012/02/01)
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- Novel cruciform structures as model compounds for coordination induced single molecule switches
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We have synthesized various molecular cruciforms consisting of two different crossing π-systems and comprising crosswise arranged thiol- and pyridine-anchor groups. With these model compounds we strive towards the investigation of a new switching concept based on the potential dependent coordination of pyridines to gold electrodes in an electrochemical set-up. Integration of these cruciform molecules between both electrodes of a mechanically controlled break junction in a liquid environment gave insight into their single molecule transport properties. These studies allowed individual transport characteristics to be assigned to the bar subunits of the cruciforms but also revealed the remaining experimental challenges to realize the suggested switching concept. Schweizerische Chemische Gesellschaft.
- Grunder, Sergio,Huber, Roman,Wu, Songmei,Schoenenberger, Christian,Calame, Michel,Mayor, Marcel
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p. 140 - 144
(2011/08/04)
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- Iron-catalyzed thioetherification of thiols with aryl iodides
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FeCl3 in combination with bisphosphine ligands represents an efficient catalyst system for the cross-coupling of aryl- and alkyl thiols with aryl iodides, a broad spectrum of functional groups can be tolerated during the catalysis. The Royal Society of Chemistry 2009.
- Wu, Jhih-Ru,Lin, Che-Hung,Lee, Chin-Fa
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supporting information; experimental part
p. 4450 - 4452
(2009/12/29)
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- Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents
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The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective ligand for SERT over other monoamine transporters. In this study, a novel library of structurally diverse 4-MTA analogues were synthesised with or without N-alkyl and/or C-α methyl or ethyl groups so that their potential SERT-dependent antiproliferative activity could be assessed. Many of the compounds displayed SERT-binding activity as well as cytotoxic activity. While there was no direct correlation between these two effects, a number of derivatives displayed anti-tumour effects in lymphoma, leukaemia and breast cancer cell lines, showing further potential to be developed as possible chemotherapeutic agents.
- Cloonan, Suzanne M.,Keating, John J.,Butler, Stephen G.,Knox, Andrew J.S.,Jorgensen, Anne M.,Peters, Guenther H.,Rai, Dilip,Corrigan, Desmond,Lloyd, David G.,Williams, D. Clive,Meegan, Mary J.
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scheme or table
p. 4862 - 4888
(2010/01/16)
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- Palladium-catalyzed carbon-sulfur cross-coupling reactions with indium tri(organothiolate) and its application to sequential one-pot processes
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(Chemical Equation Presented) It was found that indium tri(organothiolate) is an effective nucleophilic coupling partner in Pd-catalyzed C-S cross-coupling reactions to produce the functionalized sulfides in excellent yields with high atom efficiency and
- Lee, Jae-Young,Phil, Ho Lee
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supporting information; experimental part
p. 7413 - 7416
(2009/05/07)
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- Two-photon absorbing materials with quenched emission
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The present invention provides substituted phenanthroline compounds with high two photon absorption cross sections, as well as substituted phenanthroline compounds which additionally have quenched fluorescence emission upon two photon absorption.
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Page/Page column 6
(2009/01/20)
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- New cruciform structures: Toward coordination induced single molecule switches
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(Chemical Equation Presented) New cruciform structures 1-4 were synthesized to investigate a new single molecule switching mechanism arising from the interplay between the molecule and the electrode surface. These molecular cruxes consist of two rod-type
- Grunder, Sergio,Huber, Roman,Horhoiu, Viviana,Gonzalez, Maria Teresa,Schoenenberger, Christian,Calame, Michel,Mayor, Marcel
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p. 8337 - 8344
(2008/03/11)
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- Fabrication of steady junctions consisting of α, ωbis(thioacetate) oligo(p-phenylene vinylene)s in nanogap electrodes
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For obtaining molecular devices using metal-molecule-metal junctions, it is necessary to fabricate a steady conductive bridge-structure; that is stable chemical bonds need to be established from a single conductive molecule to two facing electrodes. In th
- Liang, Tien-Tzu,Naitoh, Yasuhisa,Horikawa, Masayo,Ishida, Takao,Mizutani, Wataru
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p. 13720 - 13726
(2007/10/03)
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- Nucleophilic aromatic substitution reaction of nitroarenes with alkyl- or arylthio groups in dimethyl sulfoxide by means of cesium carbonate
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Treatment of nitroarenes having electron-withdrawing groups at the ortho or para position with alkanethiol in the presence of cesium carbonate in dimethyl sulfoxide at 25°C leads to nucleophilic displacement of the nitro group with the alkylthio group. Cesium carbonate is superior to other bases such as potassium carbonate, sodium carbonate, and triethylamine. The cesium-mediated nucleophilic aromatic substitution reaction provides a mild yet powerful and user-friendly protocol for the synthesis of aryl sulfides.
- Kondoh, Azusa,Yorimitsu, Hideki,Oshima, Koichiro
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p. 2357 - 2360
(2007/10/03)
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- Novel two-photon-absorbing, 1,10-phenanthroline-containing π-conjugated chromophores and their nickel(II) chelated complexes with quenched emissions
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Novel 1,10-phenanthroline-containing π-conjugated chromophores with varied electron donors were synthesized and characterized together with their corresponding nickel(II) chelated complexes. The linear absorption maxima for these chromophores could be tun
- Zheng, Qingdong,He, Guang S.,Prasad, Paras N.
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p. 579 - 587
(2007/10/03)
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- The tert-butyl moiety - A base resistent thiol protecting group smoothly replaced by the labile acetyl moiety
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Aryl t-butyl sulfides underwent quantitative tert-butyl/acetyl exchange reactions affording thioacetic acid S-aryl esters when treated with acetyl chloride and boron tribromide.
- Stuhr-Hansen, Nicolai
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p. 641 - 646
(2007/10/03)
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- Novel synthesis of protected thiol end-capped stilbenes and oligo(phenylenevinylene)s (OPVs)
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The first general procedures for preparation of thiol end-capped stilbenes and oligo(phenylenevinylene)s (OPVs) with tert-butyl- and acetyl-protected thiol termini have been developed. These reactions proceed via Br/Li exchange, McMurry, and Wittig-type reactions. The thiol functionality is protected against strong basic and acidic reaction conditions as a t-Bu sulfide. As a key point in the method, reprotection of the thiol group is accomplished by means of acetyl chloride and boron tribromide. The novel strategy forms the basis for stepwise introduction of 4-mercaptostyryl units in OPVs. The new mono-, di-, and trimercapto OPVs have potential applications as one, two, and three terminal molecular devices in gold nanoparticle clusters, self-assembled monolayers, and optoelectronic devices.
- Stuhr-Hansen, Nicolai,Christensen, Jorn B.,Harrit, Niels,Bjornholm, Thomas
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p. 1275 - 1282
(2007/10/03)
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