88357-16-8

Usage

Uses

Used in Pharmaceutical Industry:
4-(TERT-BUTYLSULFANYL)BENZENECARBALDEHYDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure and reactivity allow for the creation of a wide range of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(TERT-BUTYLSULFANYL)BENZENECARBALDEHYDE is utilized as an intermediate in the production of agrochemicals, playing a crucial role in the synthesis of various pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Organic Chemistry:
4-(TERT-BUTYLSULFANYL)BENZENECARBALDEHYDE is employed as a versatile building block in organic chemistry for its capacity to participate in numerous chemical reactions, leading to the formation of a diverse array of organic compounds for various applications.

InChI:InChI=1/C11H14OS/c1-11(2,3)13-10-6-4-9(8-12)5-7-10/h4-8H,1-3H3

Upstream product

• 25752-90-3 tert-butyl 4-bromophenyl sulfide 
• 68-12-2 N,N-dimethyl-formamide 
• 459-57-4 4-fluorobenzaldehyde 
• 75-66-1 2-methylpropan-2-thiol 
• 555-16-8 4-nitrobenzaldehdye 
• 29364-29-2 sodium tert-butyl thiolate 
• 106-53-6 para-bromobenzenethiol 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 100538-31-6 1,2-bis[4-(formyl)phenyl]disulfane 
• 500530-77-8 (E,E)-1,4-bis[4-(tert-butylsulfanyl)styryl]benzene 
• 500530-67-6 trans-4-(tert-butylthio)stilbene 
• 500530-88-1 (E,E,E)-1,3,5-tris[4-(tert-butylthio)styryl]benzene 
• 500530-69-8 [4-(tert-butylsulfanyl)phenyl]methanol 
• 570421-75-9 trans-4,4'-bis(tert-butylthio)stilbene 
• 874486-70-1 trans-4-tert-butylthio-4'-ethylstilbene 
• 500530-70-1 (4-(bromomethyl)phenyl)(tert-butyl)sulfane 
• 500530-71-2 4-(tert-butylthio)benzyl cyanide 
• 500530-80-3 trans-4-(tert-butylthio)styrylbenzaldehyde 
• 500530-72-3 diethyl [4-(tert-butylsulfanyl)benzyl]phosphonate 

Relevant academic research and scientific papers

COMPOUNDS AND METHOD OF USE

This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

Bismuth(III)-Promoted Acetylation of Thioethers into Thioacetates

The thioacetate group is extensively employed as an anchoring group for attachment of molecules onto gold surfaces or between electrodes in molecular electronics. On account of its ready hydrolysis, it is often incorporated in the last step of a synthetic

Copper-free sonogashira coupling reaction using a trans-spanning 1,2-Bis(2-thienylethynyl)benzene ligand

Novel copper-free Sonogashira coupling reaction of aryl halides with terminal acetylenes proceeded in the presence of 1,2-bis(2-thienylethynyl) benzene (1) as a trans-bidentatable ligand.

Novel cruciform structures as model compounds for coordination induced single molecule switches

We have synthesized various molecular cruciforms consisting of two different crossing π-systems and comprising crosswise arranged thiol- and pyridine-anchor groups. With these model compounds we strive towards the investigation of a new switching concept based on the potential dependent coordination of pyridines to gold electrodes in an electrochemical set-up. Integration of these cruciform molecules between both electrodes of a mechanically controlled break junction in a liquid environment gave insight into their single molecule transport properties. These studies allowed individual transport characteristics to be assigned to the bar subunits of the cruciforms but also revealed the remaining experimental challenges to realize the suggested switching concept. Schweizerische Chemische Gesellschaft.

Iron-catalyzed thioetherification of thiols with aryl iodides

FeCl3 in combination with bisphosphine ligands represents an efficient catalyst system for the cross-coupling of aryl- and alkyl thiols with aryl iodides, a broad spectrum of functional groups can be tolerated during the catalysis. The Royal Society of Chemistry 2009.

Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents

The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective ligand for SERT over other monoamine transporters. In this study, a novel library of structurally diverse 4-MTA analogues were synthesised with or without N-alkyl and/or C-α methyl or ethyl groups so that their potential SERT-dependent antiproliferative activity could be assessed. Many of the compounds displayed SERT-binding activity as well as cytotoxic activity. While there was no direct correlation between these two effects, a number of derivatives displayed anti-tumour effects in lymphoma, leukaemia and breast cancer cell lines, showing further potential to be developed as possible chemotherapeutic agents.

Palladium-catalyzed carbon-sulfur cross-coupling reactions with indium tri(organothiolate) and its application to sequential one-pot processes

(Chemical Equation Presented) It was found that indium tri(organothiolate) is an effective nucleophilic coupling partner in Pd-catalyzed C-S cross-coupling reactions to produce the functionalized sulfides in excellent yields with high atom efficiency and

Two-photon absorbing materials with quenched emission

The present invention provides substituted phenanthroline compounds with high two photon absorption cross sections, as well as substituted phenanthroline compounds which additionally have quenched fluorescence emission upon two photon absorption.

New cruciform structures: Toward coordination induced single molecule switches

(Chemical Equation Presented) New cruciform structures 1-4 were synthesized to investigate a new single molecule switching mechanism arising from the interplay between the molecule and the electrode surface. These molecular cruxes consist of two rod-type

Nucleophilic aromatic substitution reaction of nitroarenes with alkyl- or arylthio groups in dimethyl sulfoxide by means of cesium carbonate

Treatment of nitroarenes having electron-withdrawing groups at the ortho or para position with alkanethiol in the presence of cesium carbonate in dimethyl sulfoxide at 25°C leads to nucleophilic displacement of the nitro group with the alkylthio group. Cesium carbonate is superior to other bases such as potassium carbonate, sodium carbonate, and triethylamine. The cesium-mediated nucleophilic aromatic substitution reaction provides a mild yet powerful and user-friendly protocol for the synthesis of aryl sulfides.