- Facile catalyst-free synthesis of 2-vinylquinolines via a direct deamination reaction occurring during Mannich synthesis
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A facile catalyst-free method for the synthesis of 2-vinylquinolines via a direct deamination reaction during Mannich synthesis has been developed. Instantaneous hydrogen transfer via a six-membered ring intermediate is proposed as a key step for the direct deamination reaction. This reaction strategy tolerates a broad substrate scope and provides a highly efficient way to synthesize 2-vinylquinolines with adequate yields.
- Xiao, Jichao,Huang, Ye,Song, Zilan,Feng, Wenhua
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p. 99095 - 99098
(2015/12/04)
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- Dramatically accelerated synthesis of β-aminoketones via aqueous Mannich reaction under combined microwave and ultrasound irradiation
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An efficient green chemistry approach to the synthesis of β-aminoketones was developed under combined microwave and ultrasound irradiation. With this technique, the title compounds were rapidly synthesized in aqueous media with good yields. Georg Thieme Verlag Stuttgart.
- Peng, Yanqing,Dou, Ruiling,Song, Gonghua,Jiang, Jun
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p. 2245 - 2247
(2007/10/03)
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- Microwave-assisted regioselective synthesis of β-aminoketones via the Mannich reaction
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A new and efficient method for the regioselective synthesis of β- aminoketones has been achieved by a simple reaction of formaldehyde, a secondary amine and a ketone under microwave irradiation.
- Gadhwal,Baruah,Prajapati,Sandhu
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p. 341 - 342
(2007/10/03)
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- 4-(β-arylvinyl)-3-(β-arylvinylketo)-1-ethyl-4-piperidinols and related compounds: A novel class of cytotoxic and anticancer agents
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The syntheses of a series of 1-aryl-5-diethylamino-1-penten-3-one hydrochlorides 1 and 1-aryl-3-diethylamino-1-propanone hydrochlorides 4 were accomplished. Attempts to prepare the corresponding bis(5-aryl-3-oxo-4- pentenyl)ethylamine hydrochlorides 2 and
- Dimmock, Jonathan R.,Vashishtha, Sarvesh C.,Quail, J. Wilson,Pugazhenthi, Uma,Zimpel, Zbigniew,Sudom, Athena M.,Allen, Theresa M.,Kao, Grace Y.,Balzarini, Jan,De Clercq, Erik
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p. 4012 - 4020
(2007/10/03)
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- A modified Mannich reaction using 1,3-dioxolane
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Mannich reaction of ketones using 1,3-dioxolane instead of formaldehyde, paraformaldehyde, or 1,3,5-trioxane afforded the corresponding Mannich bases in high yields. Under the same conditions the aminomethylation of aromatics did not proceed but the intramolecular aminomethylation, like a Pictet-Spengler type reaction, proceeded smoothly.
- Sumita,Koumori,Ohno
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p. 1676 - 1678
(2007/10/02)
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