88466-77-7

Basic information

• Product Name: 1-Boc-3-carbamoyl piperidine
• Synonyms: 1-Boc-3-carbamoyl piperidine;(S)-1-Boc-3-piperidinecarboxaMide;(S)-1-Boc-3-(aminocarbonyl)piperidine
• CAS NO: 88466-77-7
• Molecular Formula: C11H20N2O3
• Molecular Weight: 228.29
• Mol File: 88466-77-7.mol

Chemical Properties

• Boiling Point: 384.4 °C at 760 mmHg
• Flash Point: 186.3 °C
• Appearance: /
• Density: 1.123 g/cm³
• PKA: 16.41±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-3-carbamoyl piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-carbamoyl piperidine(88466-77-7)
• EPA Substance Registry System: 1-Boc-3-carbamoyl piperidine(88466-77-7)

Safety Data

• Hazardous Substances Data: 88466-77-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-3-carbamoyl piperidine serves as an intermediate in the production of various drugs, contributing to the development of new therapeutic agents. Its presence in the synthesis process ensures the protection of the carbamoyl group, facilitating the creation of complex molecular structures with enhanced properties.
Used in Research Chemicals:
As a building block for the synthesis of other organic compounds, 1-Boc-3-carbamoyl piperidine is instrumental in advancing chemical research. Its versatility allows for the exploration of novel chemical pathways and the creation of innovative molecules with potential applications in various fields.

Upstream product

• 88495-54-9 (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 

Downstream Products

• 916500-36-2 (S)-3-[5-(4-fluoro-benzyl)-[1,2,4]oxadiazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 915226-65-2 (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine 
• 915226-72-1 (S)-piperidine-3-carbonitrile hydrochloride 
• 915226-64-1 (S)-1-(4-fluoro-benzoyl)-piperidine-3-carbonitrile 
• 915226-39-0 (S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Substituted Oxadiazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate Receptors

The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.(I).

OXAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I), wherein P3A, W, B, Q, Rl and R2 are defined as in formula (I); invention compounds are positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the tr

PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I) as positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example, cognitive decline, both positive and negative symptoms in schizophrenia as well as other central or peripheral nervous system disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved. The invention is also directed to pharmaceutical compounds and compositions in the prevention or treatment of such diseases in which mGluKi is involved. W represents (C4-C7)cycloalkyl, (C3-C7)heterocycloalkyl , (C3-C7)heterocycloalkyl-(C1-C3)alkyl or (C3-C7)heterocycloalkenyl ring; represents a (C5-C7)heteroeycloalkyl, (C5-C7)heterocycloalkeiiyl ring or a heteroaryl group of formula (a), (b), (c), (d), (e), (f), (g), (i). Q denotes a cycloalkyl, an aryl or heteroaryl group of formula (j), (k), (l), (m), (n). A is azo -N=N-, ethyl, ethenyl, ethynyl, -NR8C(=O)-, -NR8C(=O)-O-, -NR8C(=O)-NR9, NR8S(=O)2-, -C(=O)NR8-, -O-C(=O)NR8-, -S-, -S(=O)-, -S(=O)2-, -S(C=O)2NR8-, -C(=0)-0-, -0-C(=0)-, -C(=NR8)NR9-, C(C=NOR8)NR9- , -NR8C(=NOR9)-, =N-0-, -0-N=CH- or a group aryl or heteroaryl of formula, (o), (p), (q), (r), (s), (t), (u), (v), (w), (x). The other substituents are defined in the claims.

NOVEL HETEROCYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R1 and R2 are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia.