915226-65-2

Basic information

• Product Name: (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine
• Synonyms: (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine
• CAS NO: 915226-65-2
• Molecular Weight: 265.287
• Mol File: 915226-65-2.mol

Chemical Properties

• CAS DataBase Reference: (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine(915226-65-2)
• EPA Substance Registry System: (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine(915226-65-2)

Safety Data

• Hazardous Substances Data: 915226-65-2(Hazardous Substances Data)

Upstream product

• 88495-54-9 (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 
• 403-43-0 4-fluorobenzoyl chloride 
• 915226-72-1 (S)-piperidine-3-carbonitrile hydrochloride 
• 915226-39-0 (S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 915226-64-1 (S)-1-(4-fluoro-benzoyl)-piperidine-3-carbonitrile 
• 88466-77-7 (S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 915226-31-2 (4-fluoro-phenyl)-{(S)-3-[5-(1-methyl-1H-imidazol-4-yl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-methanone 
• 915226-27-6 (S)-(4-fluorophenyl)-{3-[5-(5-fluoropyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-methanone 

Relevant articles and documents

Substituted Oxadiazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate Receptors

The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.(I).

PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I) as positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example, cognitive decline, both positive and negative symptoms in schizophrenia as well as other central or peripheral nervous system disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved. The invention is also directed to pharmaceutical compounds and compositions in the prevention or treatment of such diseases in which mGluKi is involved. W represents (C4-C7)cycloalkyl, (C3-C7)heterocycloalkyl , (C3-C7)heterocycloalkyl-(C1-C3)alkyl or (C3-C7)heterocycloalkenyl ring; represents a (C5-C7)heteroeycloalkyl, (C5-C7)heterocycloalkeiiyl ring or a heteroaryl group of formula (a), (b), (c), (d), (e), (f), (g), (i). Q denotes a cycloalkyl, an aryl or heteroaryl group of formula (j), (k), (l), (m), (n). A is azo -N=N-, ethyl, ethenyl, ethynyl, -NR8C(=O)-, -NR8C(=O)-O-, -NR8C(=O)-NR9, NR8S(=O)2-, -C(=O)NR8-, -O-C(=O)NR8-, -S-, -S(=O)-, -S(=O)2-, -S(C=O)2NR8-, -C(=0)-0-, -0-C(=0)-, -C(=NR8)NR9-, C(C=NOR8)NR9- , -NR8C(=NOR9)-, =N-0-, -0-N=CH- or a group aryl or heteroaryl of formula, (o), (p), (q), (r), (s), (t), (u), (v), (w), (x). The other substituents are defined in the claims.

NOVEL HETEROCYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R1 and R2 are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia.