885271-28-3 Usage
Uses
Used in Organic Synthesis:
5-BENZYLOXY-1H-INDAZOLE-3-CARBALDEHYDE is used as a key intermediate for the synthesis of a variety of organic molecules. Its unique structure, featuring both benzyl ether and aldehyde functional groups, allows for multiple synthetic pathways and the creation of complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-BENZYLOXY-1H-INDAZOLE-3-CARBALDEHYDE is utilized as a starting material for the development of new drugs. Its potential pharmacological activities make it a valuable compound for exploring novel therapeutic agents, particularly in the context of drug discovery and medicinal chemistry.
Used in Drug Discovery:
5-BENZYLOXY-1H-INDAZOLE-3-CARBALDEHYDE is employed as a precursor in drug discovery processes, where its chemical properties can be leveraged to design and synthesize new pharmaceutical compounds with potential therapeutic benefits.
Used in Medicinal Chemistry:
As a component in medicinal chemistry, 5-BENZYLOXY-1H-INDAZOLE-3-CARBALDEHYDE is used to study the structure-activity relationships of various drug candidates, aiding in the optimization of their pharmacological profiles for improved efficacy and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 885271-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,7 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 885271-28:
(8*8)+(7*8)+(6*5)+(5*2)+(4*7)+(3*1)+(2*2)+(1*8)=203
203 % 10 = 3
So 885271-28-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H12N2O2/c18-9-15-13-8-12(6-7-14(13)16-17-15)19-10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)
885271-28-3Relevant articles and documents
An optimized procedure for direct access to 1: H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles
Chevalier, Arnaud,Ouahrouch, Abdelaaziz,Arnaud, Alexandre,Gallavardin, Thibault,Franck, Xavier
, p. 13121 - 13128 (2018/04/23)
Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors
McBride, Christopher M.,Renhowe, Paul A.,Gesner, Thomas G.,Jansen, Johanna M.,Lin, Julie,Ma, Sylvia,Zhou, Yasheen,Shafer, Cynthia M.
, p. 3789 - 3792 (2008/12/23)
The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzy
