885273-80-3

Basic information

• Product Name: [2-(4-FLUORO-PHENYL)-OXAZOL-4-YL]-METHANOL
• Synonyms: [2-(4-FLUORO-PHENYL)-OXAZOL-4-YL]-METHANOL;2-(4-fluorophenyl)-4-Oxazolemethanol;[2-(4-Fluorophenyl)-1,3-oxazol-4-yl]methanol
• CAS NO: 885273-80-3
• Molecular Formula: C₁₀H₈FNO₂
• Molecular Weight: 193.17
• Mol File: 885273-80-3.mol

Chemical Properties

• Boiling Point: 339.0±52.0 °C(Predicted)
• Appearance: /
• Density: 1.298±0.06 g/cm3(Predicted)
• PKA: 12.98±0.10(Predicted)
• CAS DataBase Reference: [2-(4-FLUORO-PHENYL)-OXAZOL-4-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-FLUORO-PHENYL)-OXAZOL-4-YL]-METHANOL(885273-80-3)
• EPA Substance Registry System: [2-(4-FLUORO-PHENYL)-OXAZOL-4-YL]-METHANOL(885273-80-3)

Safety Data

• Hazardous Substances Data: 885273-80-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[2-(4-FLUORO-PHENYL)-OXAZOL-4-YL]-METHANOL is used as a building block or intermediate in the synthesis of various pharmaceuticals for its potential biological activity. The presence of the oxazole moiety and the fluorine-substituted phenyl group may contribute to the development of new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
[2-(4-FLUORO-PHENYL)-OXAZOL-4-YL]-METHANOL is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its potential for biological activity. Its unique structure may lead to the creation of novel compounds with improved efficacy and selectivity in agricultural applications.

Upstream product

• 916810-62-3 4-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-2-(4-fluorophenyl)-1,3-oxazole 
• 1314419-49-2 methyl 2-(4-fluorophenyl)-4,5-dihydrooxazole-4-carboxylate 
• 459-57-4 4-fluorobenzaldehyde 
• 1065102-64-8 methyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate 
• 56108-05-5 4-fluorobenzamidic acid methylester hydrochloride salt 

Downstream Products

• 152940-51-7 2-(4-fluorophenyl)oxazole-4-carbaldehyde 
• 22091-39-0 4-Chloromethyl-2-(4-fluorophenyl)oxazole 

Relevant articles and documents

Substituted N - ((1 °, 3° - [...] - 4° - yl) - methyl) - 4 - benzoyl piperidine compound and use thereof

The invention discloses a substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound represented by formula I, a preparation method thereof, and applications of the substituted N-((1', 3'-oxazole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound in preparation of antituberculous drugs. The substituted N-((1', 3'-azole-4'-yl)-methyl)-4-benzoyl-hexahydropyridine compound possesses activity on mycobacterium tuberculosis-susceptible strains, and also possesses activity on strains with tolerance on traditional first-line antituberculous drugs such as isoniazide and rifampicin, and is a novel mycobacterium tuberculosis resistant compound with a promising application prospect.

Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTB

A high-throughput screening effort on 45,000 compounds resulted in the discovery of a disubstituted oxazole as a new structural class inhibitor of Mycobacterium tuberculosis (Mtb). In order to improve the activity and investigate the SAR of this scaffold, a series of disubstituted azole analogues have been designed and synthesized. The newly synthesized compounds 1a-y were evaluated for their in vitro anti-TB activity versus replicating, multi- and extensive drug resistant Mtb strains. All the compounds, except 1o, 1p and 1q, showed potent anti-TB activity with MIC of 1-64 mg/L. The test of broad spectrum panel revealed that this series are specific to Mtb. The cytotoxicity assessment indicated that the compounds were not cytotoxic against HEK 293 cells. The compounds could have a novel mechanism to anti-Mtb as they can inhibit drug sensitive and drug resistant Mtb.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

COMPOUNDS AND METHODS

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, n and L are as defined herein, and methods of making and using the same.

Chemical Compounds

This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.