885274-41-9

Basic information

• Product Name: 2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE
• Synonyms: C-[2-(2-CHLORO-PHENYL)-OXAZOL-4-YL]-METHYLAMINE;2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE;(2-(2-Chlorophenyl)oxazol-4-yl)MethanaMine
• CAS NO: 885274-41-9
• Molecular Formula: C10H9ClN2O
• Molecular Weight: 208.64
• Mol File: 885274-41-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE(885274-41-9)
• EPA Substance Registry System: 2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE(885274-41-9)

Safety Data

• Hazardous Substances Data: 885274-41-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE is used as a building block or intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and reactivity contribute to the development of new and innovative pharmaceutical compounds.
Used in Agrochemical Development:
2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE may also have potential applications in the development of new agrochemicals. Its unique properties and reactivity can be harnessed to create novel agrochemicals with improved efficacy and selectivity.
Used in Scientific Research and Development:
The properties and potential uses of 2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE are further investigated in scientific research and development. 2-(2-CHLORO-PHENYL)-OXAZOL-4-YL-METHYLAMINE's unique structure and reactivity make it a promising candidate for exploration in various scientific fields, potentially leading to new discoveries and applications.

Upstream product

• 118-91-2 ortho-chlorobenzoic acid 
• 609-66-5 2-chlorobenzamide 

Relevant articles and documents

Design, synthesis, and insecticidal/acaricidal evaluation of novel pyrimidinamine derivatives containing phenyloxazole moiety

A series of novel pyrimidinamine derivatives containing phenyloxazole moiety were designed and synthesized, and their structures were characterized by 1H NMR, MS, and elemental analyses. The bioassay results displayed that some compounds exhibited remarkable insecticidal activities against Aphis fabae and Tetranychus cinnabarinus. Especially, 5-chloro-6-ethyl-2-methyl-N-((2-(p-tolyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9o) showed potent activity against A. fabae, superior to that of the commercial insecticide, imidacloprid. In addition, 5-chloro-6-ethyl-2-methyl-N-((2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9r) showed potent activities against T. cinnabarinus, inferior to that of the commercial insecticide spirotetramat. The structure–activity relationship study for the target compounds was also discussed.

Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring

Pyrazolecarboxamide fungicides are one of the most important classes of agricultural fungicides, which belong to succinodehydrogenase inhibitors (SDHIS). To discover new pyrazolecarboxamide analogues with broad spectrum and high activity, a class of new compounds of pyrazole carboxamide derivatives containing thiazole or oxazole ring were designed by scaffold hopping and bioisosterism, and 36 pyrazole carboxamide derivatives with antifungal activity were synthesized. Those compounds were evaluated against five phytopathogenic fungi, Gibberella zeae, Phytophythora capsici, Sclerotonia sclerotiorum, Erysiphe graminis and Puccinia sorghi. The results indicated that most of the compounds displayed good fungicidal activities, especially against E. graminis. Theoretical calculations were carried out at the B3LYP/6-31G (d, p) level and the full geometry optimization was carried out using the 6-31G (d, p) basis set, and the frontier orbital energy, atomic net charges, molecular docking were discussed, and the structure-activity relationships were also studied.

Synthesis and insecticidal activities of novel 1H-pyrazole-5-carboxylic acid derivatives

Fourteen 1H-pyrazole-5-carboxylic acid derivatives containing oxazole and thiazole rings were synthesized and characterized by 1H NMR, mass spectrometry and elemental analysis. Most target compounds were obtained in overall yields in the range of 30-50%. The insecticidal activities of these new compounds against Aphis fabae were evaluated. The bioassays' results indicate that some of these compounds exhibit good activities, especially compound 7h which shows 85.7% mortality against A. fabae at a concentration of 12.5 mg/L. This activity is comparable to that of the commercial insecticide imidacloprid.