609-66-5

Basic information

• Product Name: 2-Chlorobenzamide
• Synonyms: 2-CHLOROBENZAMIDE;TIMTEC-BB SBB004023;O-CHLORO-BENZAMIDE;2-chloro-benzamid;o-chloro-benzamid;2-Chlorobenzamide o-Chlorobenzamide;2-Chlorobenzamide,97%;2-Chlorbenzamid
• CAS NO: 609-66-5
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• EINECS: 210-195-6
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Anilines, Amides & Amines;Chlorine Compounds;Amides;Carbonyl Compounds;Organic Building Blocks;API Intermediate
• Mol File: 609-66-5.mol
• Article Data: 139

Chemical Properties

• Melting Point: 142-144 °C(lit.)
• Boiling Point: 275ºC
• Flash Point: 120.1 ºC
• Appearance: /
• Density: 1.2187 (rough estimate)
• Vapor Pressure: 0.00521mmHg at 25°C
• Refractive Index: 1.5618 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.36±0.50(Predicted)
• BRN: 508510
• CAS DataBase Reference: 2-Chlorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chlorobenzamide(609-66-5)
• EPA Substance Registry System: 2-Chlorobenzamide(609-66-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-20/22
• Safety Statements: 36-37/39-26
• WGK Germany: 1
• RTECS: CV2443737
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 609-66-5(Hazardous Substances Data)

Usage

Chemical Properties

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General Description

2-Chlorobenzamide is the major degradation product of CCU (1-(2-chlorobenzoyl)-3-(4-chlorophenyl) urea), a new insect growth regulator. It undergoes room temperature Pd-mediated hydrodehalogenations with KF and polymethylhydrosiloxane (PMHS) to yield benzamide. t undergoes reduction with NaBH4 in diglyme at 162°C to yield 2-chlorobenzonitrile.

InChI:InChI=1/C7H6ClNO/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H2,9,10)

Upstream product

• 63417-79-8 2-chloro-benzimidic acid ethyl ester; hydrochloride 
• 60-35-5 acetamide 
• 118-91-2 ortho-chlorobenzoic acid 
• 609-65-4 o-chlorobenzoyl chloride 
• 89-98-5 2-chloro-benzaldehyde 
• 23564-81-0 N-phenyl-2-(2-chlorophenyl)formamidine 
• 100-51-6 benzyl alcohol 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 55-21-0 benzamide 
• 873-32-5 2-Chlorobenzonitrile 
• 75-52-5 nitromethane 
• 5000-66-8 2-chlorophenacyl bromide 
• 1429790-14-6 methyl 3-(2-chlorophenyl)-3-oxopropanedithioate 
• 873-31-4 2-chlorophenylacetylene 

Downstream Products

• 7047-16-7 (2-chloro-benzoyl)-dithiocarbamic acid methyl ester 
• 110968-64-4 (2-Chloro-phenyl)-(3-trichloromethyl-2-aza-bicyclo[2.2.1]hept-5-en-2-yl)-methanone 
• 3574-96-7 2-(2-chlorophenyl)-1H-benzimidazole 
• 1202784-86-8 C₁₀H₈ClNO 
• 4765-50-8 2-(2-chlorophenyl)quinazolin-4(3H)-one 
• 147-14-8 copper phthalocyanine 
• 374697-00-4 ethyl 3-(2-chlorobenzamido)propanoate 
• 1122008-50-7 butyl 3-(2-chlorobenzamido)propanoate 
• 1039204-90-4 2-chloro-N-(2-oxocyclobutyl)benzamide 
• 349138-08-5 C₁₃H₁₄ClNO₃ 
• 125732-77-6 N-[[[[2-[1-(2,3-Dihydro-2,2-dimethylbenzofuran-5-yl)-2,2,3,3,3-pentafluoropropoxy]-3-methyl]pyridin-5-yl]amino]carbonyl]-2-chlorobenzamide 
• 40478-17-9 N-{[Bis-(2-chloro-ethyl)-amino]-methyl}-2-chloro-benzamide 
• 6120-56-5 2-Chlorallyl-N-(2-chlor-benzoyl)-carbamat 

Relevant articles and documents

Solid-phase synthesis of diaryl ketones through a three-component Stille coupling reaction

A three-component Stille coupling reaction on solid phase is described. Diaryl ketones bearing a wide variety of functional groups were prepared with polymer-bound organostannane and aryl halides in the presence of carbon monoxide.

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Cu(II)-promoted oxidative C-N bond cleavage of N-benzoylamino acids to primary aryl amides

A novel protocol for CuCl2-promoted oxidative C-N bond cleavage of N-benzoyl amino acids was developed. It is the first example of using accessible amino acid as an ammonia synthetic equivalent for the synthesis of primary aryl amides via CuCl2-promoted oxidative C-N bond cleavage reaction. The present protocol shows excellent functional group tolerance and provides an alternative method for the synthetic of primary aryl amides in 84-96% yields.

Nano-construction of CuO nanorods decorated with g-C3N4 nanosheets (CuO/g-C3N4-NS) as a superb colloidal nanocatalyst for liquid phase C[sbnd]H conversion of aldehydes to amides

Herein, we describe an intelligent strategy to fabricate nanosheets of graphitic carbon nitride (g-C3N4) decorated with nanorods copper oxide (CuO NRs). Then, the catalytic activity of CuONRs/g-C3N4-NS was developed for the synthesis of primary amides in water. The morphology of CuO and its synergetics effect with nanosheets g-C3N4 a major role in the yield of products. Furthermore, hydroxylamine hydrochloride (NH2OH·HCl) due to availability and affordability was used as a suitable substitute for ammonia source. The findings demonstrate that this layer nanostructure is a superb catalyst for converting various derivatives of aldehyde to their corresponding amides. The current protocol can be useful criterion in the synthesis and stabilization of metal oxides and provides new insight in organic transformation.