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885277-09-8

QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYLis a heterocyclic chemical compound belonging to the class of quinazolines. It features two fused six-membered rings with a nitrogen atom and contains a chlorine and fluorine atom, as well as a phenyl group in its structure. This quinazoline derivative is utilized in medicinal chemistry and pharmaceutical research as a building block for synthesizing various biologically active compounds.

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  • 885277-09-8 Structure

  • Basic information

    1. Product Name: QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-
    2. Synonyms: QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-
    3. CAS NO:885277-09-8
    4. Molecular Formula: C14H8ClFN2
    5. Molecular Weight: 258.68
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 885277-09-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 304.8±24.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.351±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 0.01±0.30(Predicted)
    10. CAS DataBase Reference: QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-(CAS DataBase Reference)
    11. NIST Chemistry Reference: QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-(885277-09-8)
    12. EPA Substance Registry System: QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-(885277-09-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 885277-09-8(Hazardous Substances Data)

885277-09-8 Usage

Uses

Used in Pharmaceutical Industry:
QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYLis used as a building block for the synthesis of biologically active compounds for the development of new drug candidates and potential therapeutic agents. Its structural features make it a valuable tool in medicinal chemistry and pharmaceutical research, particularly for creating anti-cancer and anti-inflammatory agents.

Check Digit Verification of cas no

The CAS Registry Mumber 885277-09-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,7 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 885277-09:
(8*8)+(7*8)+(6*5)+(5*2)+(4*7)+(3*7)+(2*0)+(1*9)=218
218 % 10 = 8
So 885277-09-8 is a valid CAS Registry Number.

885277-09-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-6-fluoro-2-phenylquinazoline

1.2 Other means of identification

Product number -
Other names 4-Chloro-6-fluoro-2-phenyl-quinazoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:885277-09-8 SDS

885277-09-8Relevant articles and documents

The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells

Hour, Mann-Jen,Yang, Jai-Sing,Chen, Tai-Lin,Chen, Kuan-Tin,Kuo, Sheng-Chu,Chung, Jing-Gung,Lu, Chi-Cheng,Chen, Chia-Yi,Chuang, Yi-Hsuan

, p. 2709 - 2721 (2011/06/27)

We designed the 6-fluoro-2-(3-fluorophenyl)-4-substituted anilinoquinazoline derivatives as less toxic anti-cancer candidates. Our result demonstrated that LJJ-10 has greater cytotoxicity than that of the other compounds in human osteogenic sarcoma U-2 OS cells. LJJ-10-induced apoptosis was associated with enhancing ROS generation, DNA damage, and an increase of the protein levels of Fas, FasL, FADD, caspase-8, cytochrome c, Apaf-1, AIF, Endo G, caspase-9 and caspase-3 in U-2 OS cells. LJJ-10-triggered growth inhibition was significantly attenuated by N-acetylcysteine, cyclosporine A, anti-FasL monoclonal antibody, and caspase-8, -9 and -3 specific inhibitors in U-2 OS cells. We suggest that LJJ-10-induced apoptotic cell death in U-2 OS cells through death receptor- and mitochondria-dependent apoptotic signaling pathways.

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