QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-

Base Information

• Chemical Name: QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-
• CAS No.: 885277-09-8
• Molecular Formula: C14H8 Cl F N2
• Molecular Weight: 258.682
• Mol file: 885277-09-8.mol

Synonyms:QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-

Chemical Property of QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-

Chemical Property:

• Boiling Point: 304.8±24.0 °C(Predicted)
• PKA: 0.01±0.30(Predicted)
• PSA: 25.78000
• Density: 1.351±0.06 g/cm3(Predicted)
• LogP: 4.08930

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-6-fluoro-2-phenylquinazoline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL-

There total 5 articles about QUINAZOLINE, 4-CHLORO-6-FLUORO-2-PHENYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-fluoro-2-phenyl-3H,4H-quinazolin-4-one (371945-79-8) → C14H8ClFN2 (885277-09-8)

Guidance literature:

With thionyl chloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 50 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2011.03.059

Reference yield:

5-fluoro-2-nitrobenzoic acid (320-98-9) → C14H8ClFN2 (885277-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 1,2-dichloro-ethane / 4 h / Reflux

2: ammonia / 1,2-dichloro-ethane / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol

4: sodium hydrogensulfite / N,N-dimethyl acetamide / 3 h / 150 °C

With thionyl chloride; palladium 10% on activated carbon; ammonia; hydrogen; sodium hydrogensulfite; In methanol; N,N-dimethyl acetamide; 1,2-dichloro-ethane;

DOI:10.1016/j.ejmech.2011.03.059

Reference yield:

5-fluoro-2-nitrobenzoyl chloride (394-02-5) → C14H8ClFN2 (885277-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / 1,2-dichloro-ethane / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol

3: sodium hydrogensulfite / N,N-dimethyl acetamide / 3 h / 150 °C

4: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0.5 h / 50 °C

With thionyl chloride; palladium 10% on activated carbon; ammonia; hydrogen; sodium hydrogensulfite; In methanol; N,N-dimethyl acetamide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.03.059

upstream raw materials:

6-fluoro-2-phenyl-3H,4H-quinazolin-4-one

5-fluoro-2-nitrobenzoic acid

5-fluoro-2-nitrobenzoyl chloride

2-amino-5-fluorobenzamide

Downstream raw materials:

4-anilino-6-fluoro-2-phenylquinazoline

Refernces