88547-24-4

Basic information

• Product Name: AC-4,5-DEHYDRO-LEU-OH
• Synonyms: N-ALPHA-ACETYL-4,5-DEHYDRO-L-LEUCINE;AC-DEHYDROLEU-OH;AC-4,5-DEHYDRO-LEUCINE;AC-4,5-DEHYDRO-LEU-OH;AC-4,5-DEHYDRO-L-LEUCINE;AC-LEU(4,5-DEHYDRO)-OH;Ac-4,5-dehydro-L-Leu-OH
• CAS NO: 88547-24-4
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.19
• Mol File: 88547-24-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: AC-4,5-DEHYDRO-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: AC-4,5-DEHYDRO-LEU-OH(88547-24-4)
• EPA Substance Registry System: AC-4,5-DEHYDRO-LEU-OH(88547-24-4)

Safety Data

• Hazardous Substances Data: 88547-24-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
AC-4,5-DEHYDRO-LEU-OH is used as a building block for the development of pharmaceutical drugs due to its unique chemical properties and potential therapeutic effects.
Used in Antimicrobial Applications:
AC-4,5-DEHYDRO-LEU-OH is used as an antimicrobial agent for its potential to combat various types of infections.
Used in Neurological Disorder Treatment:
AC-4,5-DEHYDRO-LEU-OH is used as a therapeutic agent for the treatment of neurological disorders, given its potential role in influencing neurological pathways and functions.
Used in Cancer Treatment:
AC-4,5-DEHYDRO-LEU-OH is used as a potential cancer treatment, as it has been investigated for its possible impact on cancer cells and tumor growth.
Used in Peptide and Protein Synthesis:
AC-4,5-DEHYDRO-LEU-OH is used as a component in the synthesis of peptide and protein molecules, contributing to the development of new bioactive compounds and therapeutic agents.

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Relevant articles and documents

Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities

Cyclomarins are cyclic heptapeptides containing four unusual amino acids. New synthetic protocols toward their synthesis have been developed, leading to the synthesis and biological evaluation of three natural occurring cyclomarins. Interestingly, cyclomarins address two completely different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), as well as PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria.

Peptides containing γ,δ,-dihydroxy-L-leucine

(Chemical Equation Presented) (±)-Dehydroleucine was prepared and resolved by porcine kidney acylase. Under the conditions of the Sharpless asymmetric dihydroxylation (SAD), employing AD-mix-α, Nα- carbobenzyloxy-(2S)-4,5-dehydroleucine methyl ester (16)

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Eponemycin, an antibiotic with a highly potent and specific antitumor activity against B16 melanoma cells in vivo, has been synthesized. The framework of the western half of the molecule was built up from N-trityl- γ,δ-didehydroleucinal and the dilithium