885519-56-2

Basic information

• Product Name: 1H-Indazole,6-chloro-4-iodo-
• Synonyms: 1H-Indazole,6-chloro-4-iodo-
• CAS NO: 885519-56-2
• Molecular Formula: C₇H₄ClIN₂
• Molecular Weight: 278.47753
• Mol File: 885519-56-2.mol

Chemical Properties

• Boiling Point: 388.2±22.0 °C(Predicted)
• Appearance: /
• Density: 2.156
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.78±0.40(Predicted)
• CAS DataBase Reference: 1H-Indazole,6-chloro-4-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole,6-chloro-4-iodo-(885519-56-2)
• EPA Substance Registry System: 1H-Indazole,6-chloro-4-iodo-(885519-56-2)

Safety Data

• Hazardous Substances Data: 885519-56-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1H-Indazole,6-chloro-4-iodois used as a research compound for the development of new pharmaceuticals, due to its unique chemical structure and potential interactions with biological targets.
Used in Organic Synthesis:
1H-Indazole,6-chloro-4-iodois used as a synthetic intermediate for the preparation of various organic compounds, leveraging its reactive functional groups and structural features to facilitate the synthesis of complex molecules.

Upstream product

• 35572-79-3 5-chloro-2-methyl-1,3-dinitro-benzene 

Downstream Products

• 1254036-86-6 6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1364802-72-1 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1364799-92-7 C₇H₈O₃S*C₂₆H₂₈N₆O 
• 1254036-90-2 {2-[6-{1-[(1,1-dimethylethyl)(dimethyl)silyl]-1H-indol-4-yl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol 
• 1254036-82-2 methyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 1254036-81-1 ethyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 1254036-68-4 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide 
• 1254036-91-3 6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1254036-89-9 ethyl 2-[6-{1-[(1,1-dimethylethyl)(dimethyl)silyl]-1H-indol-4-yl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 1254036-87-7 N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide 

Relevant articles and documents

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.