1H-Indazole,6-chloro-4-iodo-

Base Information

• Chemical Name: 1H-Indazole,6-chloro-4-iodo-
• CAS No.: 885519-56-2
• Molecular Formula: C7H4 Cl I N2
• Molecular Weight: 278.48
• Hs Code.: 2933990090
• Mol file: 885519-56-2.mol

Synonyms:1H-Indazole,6-chloro-4-iodo;RW3742;

Chemical Property of 1H-Indazole,6-chloro-4-iodo-

Chemical Property:

• Boiling Point: 388.2±22.0 °C(Predicted)
• PKA: 11.78±0.40(Predicted)
• PSA: 28.68000
• Density: 2.156
• LogP: 2.82090
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-4-iodo-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole,6-chloro-4-iodo-

There total 1 articles about 1H-Indazole,6-chloro-4-iodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-methyl-1,3-dinitro-benzene (35572-79-3) → 6-chloro-4-iodo-1H-indazole (885519-56-2)

Guidance literature:

Multi-step reaction with 4 steps

1: diammonium sulfide / water; ethanol

2: sodium nitrite

3: nickel; hydrazine hydrate

4: acetic acid; acetic anhydride

With diammonium sulfide; acetic anhydride; nickel; hydrazine hydrate; acetic acid; sodium nitrite; In ethanol; water;

DOI:10.1021/acs.oprd.0c00486

Reference yield: 100.0%

6-chloro-4-iodo-1H-indazole (885519-56-2) + benzenesulfonyl chloride (98-09-9) → 6-chloro-4-iodo-1-(phenylsulfonyl)-1H-indazole (1254036-94-6)

Guidance literature:

6-chloro-4-iodo-1H-indazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -15 ℃; for 0.5h;

benzenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at -15 - 20 ℃;

DOI:10.1021/acs.jmedchem.5b00767

Reference yield:

6-chloro-4-iodo-1H-indazole (885519-56-2) → 6-chloro-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole (1254036-85-5,1364801-65-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / tetrahydrofuran / 1.05 h / 17 - 23 °C / Inert atmosphere

1.2: 1.17 h / 25 °C

2.1: lithium hexamethyldisilazane; zinc(II) chloride / tetrahydrofuran / 1.25 h / -15 - -5 °C / Inert atmosphere

2.2: 6 h / 57 - 63 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0.5 h / -3 - 3 °C / Inert atmosphere

4.1: dibromotriphenylphosphorane / dichloromethane / 0.33 h / 7 - 13 °C / Inert atmosphere

5.1: triethylamine / acetone / 2.5 h / 20 - 25 °C / Inert atmosphere

With diisobutylaluminium hydride; triethylamine; sodium hydroxide; zinc(II) chloride; lithium hexamethyldisilazane; dibromotriphenylphosphorane; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; dichloromethane; acetone; toluene;

upstream raw materials:

5-chloro-2-methyl-1,3-dinitro-benzene

Downstream raw materials:

6-chloro-4-iodo-1-(phenylsulfonyl)-1H-indazole

ethyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate

methyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate

{2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol

Refernces