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5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE is a pyridine derivative with the molecular formula C6H3BrF3NO, featuring a bromine atom and three trifluoromethoxy groups. It is a chemical compound known for its reactivity, versatility, and unique structure, making it a valuable reagent in organic synthesis and an important intermediate in the development of new materials and functional molecules.

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  • 886371-77-3 Structure
  • Basic information

    1. Product Name: 5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE
    2. Synonyms: 5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE
    3. CAS NO:886371-77-3
    4. Molecular Formula: C6H3BrF3NO
    5. Molecular Weight: 241.9933296
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 886371-77-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 157.1±35.0℃ (760 Torr)
    3. Flash Point: 48.8±25.9℃
    4. Appearance: /
    5. Density: 1.737±0.06 g/cm3 (20 ºC 760 Torr)
    6. Vapor Pressure: 3.61mmHg at 25°C
    7. Refractive Index: 1.474
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: -2.54±0.29(Predicted)
    11. CAS DataBase Reference: 5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE(886371-77-3)
    13. EPA Substance Registry System: 5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE(886371-77-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 886371-77-3(Hazardous Substances Data)

886371-77-3 Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE is used as a building block in the synthesis of pharmaceuticals for its reactivity and versatility, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE is used as a key intermediate in the synthesis of agrochemicals, aiding in the creation of effective pesticides and other agricultural chemicals.
Used in Fine Chemicals Synthesis:
5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE is utilized as a versatile reagent in the synthesis of various fine chemicals, including specialty chemicals and advanced materials.
Used in Chemical Research:
5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE is employed as a research compound in chemical laboratories, facilitating studies on new reactions, mechanisms, and the development of innovative synthetic methods.
Used in Material Science:
5-BROMO-2-TRIFLUOROMETHOXY-PYRIDINE is used as an intermediate in the development of new materials and functional molecules, owing to its unique structure and properties, which can be tailored for specific applications in material science.

Check Digit Verification of cas no

The CAS Registry Mumber 886371-77-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,3,7 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 886371-77:
(8*8)+(7*8)+(6*6)+(5*3)+(4*7)+(3*1)+(2*7)+(1*7)=223
223 % 10 = 3
So 886371-77-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrF3NO/c7-4-1-2-5(11-3-4)12-6(8,9)10/h1-3H

886371-77-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromo-2-(trifluoromethoxy)pyridine

1.2 Other means of identification

Product number -
Other names 5-BROMO-2-TRIFLUOROMETHOXYPYRIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:886371-77-3 SDS

886371-77-3Downstream Products

886371-77-3Relevant articles and documents

Regioselective Synthesis of N-Heteroaromatic Trifluoromethoxy Compounds by Direct O-CF3 Bond Formation

Liang, Apeng,Han, Shuaijun,Liu, Zhenwei,Wang, Liang,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng

, p. 5102 - 5106 (2016)

The first one-step method for the synthesis of ortho-N-heteroaromatic trifluoromethoxy derivatives by site-specific O-CF3 bond formation using hydroxylated N-heterocycles and Togni's reagent is described. The approach enables the unprecedented syntheses of a wide range of six or five-membered N-heteroaromatic trifluoromethoxy compounds containing one or two heteroatoms from most commonly used hydroxylated N-heterocycles. Notable advantages of this method include its simplicity and mild conditions, avoidance of the need for metals or toxic reagents, and compatibility with a variety of functional groups. Furthermore, this method is especially suitable for the larger scale application.

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