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High Quality 99% 887144-97-0 Togni's Reagent Manufacturer
Cas No: 887144-97-0
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
1-TrifluoroMethyl-3,3-diMethyl-1,2-benziodoxole
Cas No: 887144-97-0
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Cas No: 887144-97-0
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Cas No: 887144-97-0
USD $ 10.0-10.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Shanghai Hohance Chemical Co., ltd Contact Supplier
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Cas No: 887144-97-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent
Cas No: 887144-97-0
No Data 1 Kilogram 10 Metric Ton/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier
High Purity CAS 887144-97-0 with best quality
Cas No: 887144-97-0
USD $ 146.0-176.0 / Gram 10 Gram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole CAS 887144-97-0
Cas No: 887144-97-0
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
887144-97-0 1,2-Benziodoxole,3,3-dimethyl-1-(trifluoromethyl)-
Cas No: 887144-97-0
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
CAS NO.:887144-97-0
Cas No: 887144-97-0
No Data No Data 10000 Metric Ton/Month Henan Wentao Chemical Product Co., Ltd. Contact Supplier

887144-97-0 Usage

Description

1,3-dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is in the form of colorless, white solid. It is soluble in all common organic solvents. It is used as effective and very versatile reagent for trifluoromethylation reactions of a variety of compounds including secondary and primary aryland alkylphospines, phenols, peptides containing cysteine residues by SPPS and electrophilic S-trifluoromethylation, arenes and N-heterocycles, and electrophilic N-trifluoromethylation of arozoles.

Reference

J. Charpentier, N. Früh, A. Togni, Electrophilic Trifluoromethylation by use of hypervalent iodine reagents, Chemical Reviews, 2015, vol. 115, pp. 650-682

Chemical Properties

White to light yellow solid

Uses

Mild, electrophilic, hypervalent iodine CF3 reagent effective for the trifluoromethylation of a wide range of substrates.
InChI:InChI=1/C10H10F3IO/c1-9(2)7-5-3-4-6-8(7)14(15-9)10(11,12)13/h3-6H,1-2H3

887144-97-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (T2624)  1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole  >97.0%(HPLC) 887144-97-0 1g 1,690.00CNY Detail
TCI America (T2624)  1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole  >97.0%(HPLC) 887144-97-0 5g 5,390.00CNY Detail
Aldrich (696641)  3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole  95% 887144-97-0 696641-250MG 772.20CNY Detail
Aldrich (696641)  3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole  95% 887144-97-0 696641-1G 2,469.87CNY Detail
Aldrich (696641)  3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole  95% 887144-97-0 696641-5G 10,143.90CNY Detail
Aldrich (754218)  3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole  98% 887144-97-0 754218-100MG 478.53CNY Detail
Aldrich (754218)  3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole  98% 887144-97-0 754218-500MG 1,404.00CNY Detail

887144-97-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole

1.2 Other means of identification

Product number -
Other names 3,3-dimethyl-1-(trifluoromethyl)-1λ<sup>3</sup>,2-benziodoxole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:887144-97-0 SDS

887144-97-0Synthetic route

1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole
69352-04-1

1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
With fluoride In acetonitrile93%
With potassium acetate; tetrabutylammonium triphenyldifluorosilicate In acetonitrile at -17 - 20℃; for 22h;89%
Stage #1: 1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole With potassium acetate In acetonitrile at 20℃; for 1h; Schlenk technique; Inert atmosphere;
Stage #2: (trifluoromethyl)trimethylsilane With tetrabutylammonium triphenyldifluorosilicate In acetonitrile at -17 - 20℃; for 19h; Schlenk technique; Inert atmosphere;
85%
(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

3,3-dimethyl-1λ3-benzo[d][1,2]iodoxol-1(3H)-yl acetate
175786-58-0

3,3-dimethyl-1λ3-benzo[d][1,2]iodoxol-1(3H)-yl acetate

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
With cesium fluoride In acetonitrile at 23℃; for 16h; Inert atmosphere; Darkness;77%
With cesium fluoride In acetonitrile at 20℃; for 16h;46%
With fluoride
1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole
69352-04-1

1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / acetonitrile / 15 h / 20 °C
2: 46 percent / CsF / acetonitrile / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium fluoride / acetonitrile / 12 h / 20 °C / Inert atmosphere
2: (trifluoromethyl)trimethylsilane / acetonitrile / 1 h / -10 °C / Inert atmosphere
View Scheme
2-(2-iodophenyl)propan-2-ol
69352-05-2

2-(2-iodophenyl)propan-2-ol

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tBuOCl
2: 100 percent / acetonitrile / 15 h / 20 °C
3: 46 percent / CsF / acetonitrile / 16 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: trichloroisocyanuric acid / acetonitrile / 0.17 h / 75 °C / Inert atmosphere; Reflux
2: potassium fluoride / acetonitrile / 12 h / 20 °C / Inert atmosphere
3: (trifluoromethyl)trimethylsilane / acetonitrile / 1 h / -10 °C / Inert atmosphere
View Scheme
2-Iodobenzoic acid
88-67-5

2-Iodobenzoic acid

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 23 °C
2.1: diethyl ether / 3 h / 0 - 23 °C / Inert atmosphere
2.2: 1 h / 23 °C / Inert atmosphere
3.1: acetonitrile / 16 h / 23 °C / Inert atmosphere; Darkness
4.1: cesium fluoride / acetonitrile / 16 h / 23 °C / Inert atmosphere; Darkness
View Scheme
o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diethyl ether / 3 h / 0 - 23 °C / Inert atmosphere
1.2: 1 h / 23 °C / Inert atmosphere
2.1: acetonitrile / 16 h / 23 °C / Inert atmosphere; Darkness
3.1: cesium fluoride / acetonitrile / 16 h / 23 °C / Inert atmosphere; Darkness
View Scheme
Multi-step reaction with 4 steps
1: diethyl ether / -30 °C / Inert atmosphere
2: trichloroisocyanuric acid / acetonitrile / 0.17 h / 75 °C / Inert atmosphere; Reflux
3: potassium fluoride / acetonitrile / 12 h / 20 °C / Inert atmosphere
4: (trifluoromethyl)trimethylsilane / acetonitrile / 1 h / -10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium / diethyl ether / 16.67 h / 0 - 20 °C / Inert atmosphere; Reflux
2.1: tert-butylhypochlorite / dichloromethane / 17 h / 0 °C / Darkness; Inert atmosphere
3.1: potassium acetate / acetonitrile / 1 h / 20 °C / Schlenk technique; Inert atmosphere
3.2: 19 h / -17 - 20 °C / Schlenk technique; Inert atmosphere
View Scheme
1-fluoro-3,3-dimethyl-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole
1391728-13-4

1-fluoro-3,3-dimethyl-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
With (trifluoromethyl)trimethylsilane In acetonitrile at -10℃; for 1h; Inert atmosphere;29.7 g
2-carbomethoxyaniline
134-20-3

2-carbomethoxyaniline

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sulfuric acid; sodium nitrite / water / 0 - 7 °C / Inert atmosphere
1.2: 1.58 h / -5 - 80 °C / Inert atmosphere
2.1: diethyl ether / -30 °C / Inert atmosphere
3.1: trichloroisocyanuric acid / acetonitrile / 0.17 h / 75 °C / Inert atmosphere; Reflux
4.1: potassium fluoride / acetonitrile / 12 h / 20 °C / Inert atmosphere
5.1: (trifluoromethyl)trimethylsilane / acetonitrile / 1 h / -10 °C / Inert atmosphere
View Scheme
1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole
69352-04-1

1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole

trifluoromethan
75-46-7

trifluoromethan

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
Stage #1: trifluoromethan With C12H24KO6(1+)*C13H25B3N3(1-) In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: 1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
78 %Spectr.
Stage #1: trifluoromethan With 18-crown-6 ether; benzyl potassium; hexamethylborazine In tetrahydrofuran at 0℃; for 1.33333h; Sealed tube;
Stage #2: 1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole In tetrahydrofuran at 0℃;
1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole
69352-04-1

1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole

C4H8O*C12H24KO6(1+)*C7H18B3F3N3(1-)

C4H8O*C12H24KO6(1+)*C7H18B3F3N3(1-)

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
In tetrahydrofuran at 25℃; for 0.166667h; Inert atmosphere; Glovebox;78 %Spectr.
1-fluoro-3,3-dimethyl-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole
1391728-13-4

1-fluoro-3,3-dimethyl-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

Togni's reagent
887144-97-0

Togni's reagent

Conditions
ConditionsYield
With tetrabutylammonium triphenyldifluorosilicate In acetonitrile at -20 - 20℃; for 1.5h;
Togni's reagent
887144-97-0

Togni's reagent

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2564-83-2, 45842-10-2

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

N,N-dibenzylhydroxylamine
621-07-8

N,N-dibenzylhydroxylamine

2,2,6,6-tetramethyl-1-(trifluoromethoxy)piperidine
1335135-19-7

2,2,6,6-tetramethyl-1-(trifluoromethoxy)piperidine

Conditions
ConditionsYield
Concentration; Inert atmosphere;100%
Togni's reagent
887144-97-0

Togni's reagent

L-cysteine ethyl ester hydrochloride
868-59-7

L-cysteine ethyl ester hydrochloride

(R)-ethyl 2-amino-3-((trifluoromethyl)thio)propanoate hydrochloride

(R)-ethyl 2-amino-3-((trifluoromethyl)thio)propanoate hydrochloride

Conditions
ConditionsYield
In methanol99%
In methanol at -78 - 20℃; for 1h; Schlenk technique; Inert atmosphere;97%
Togni's reagent
887144-97-0

Togni's reagent

C10H14N4O4S

C10H14N4O4S

C11H13F3N4O4S

C11H13F3N4O4S

Conditions
ConditionsYield
at -78℃;99%
Togni's reagent
887144-97-0

Togni's reagent

L-cysteine methyl ester hydrochloride
18598-63-5

L-cysteine methyl ester hydrochloride

methyl S-trifluoromethyl-(L)-cysteinate hydrochloride

methyl S-trifluoromethyl-(L)-cysteinate hydrochloride

Conditions
ConditionsYield
at -78℃;99%
Togni's reagent
887144-97-0

Togni's reagent

5-pentenylbenzoate
29264-40-2

5-pentenylbenzoate

(E)-6,6,6-trifluorohex-4-en-1-yl benzoate

(E)-6,6,6-trifluorohex-4-en-1-yl benzoate

Conditions
ConditionsYield
With 2-iodobenzoic acid potassium salt In N,N-dimethyl-formamide at 80℃; for 12h; Reagent/catalyst; Concentration; Solvent; Schlenk technique;99%
Togni's reagent
887144-97-0

Togni's reagent

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

3-bromostyrene
2039-86-3

3-bromostyrene

C10H7BrF3N

C10H7BrF3N

Conditions
ConditionsYield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole} In acetonitrile at -20 - 20℃; for 1h; Sealed tube; Inert atmosphere; enantioselective reaction;99%
Togni's reagent
887144-97-0

Togni's reagent

(E)-3-(3-methoxyphenyl)-1-phenylbut-3-en-1-one oxime

(E)-3-(3-methoxyphenyl)-1-phenylbut-3-en-1-one oxime

(S)-5-(3-methoxyphenyl)-3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

(S)-5-(3-methoxyphenyl)-3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

Conditions
ConditionsYield
With C30H39N3O2S; copper diacetate In chloroform at -10℃; for 72h; Inert atmosphere; Schlenk technique; Sealed tube; Molecular sieve; enantioselective reaction;99%
Togni's reagent
887144-97-0

Togni's reagent

(E)-3-(naphthalen-2-yl)-1-phenylbut-3-en-1-one oxime

(E)-3-(naphthalen-2-yl)-1-phenylbut-3-en-1-one oxime

(S)-5-(naphthalen-2-yl)-3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

(S)-5-(naphthalen-2-yl)-3-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

Conditions
ConditionsYield
With C30H39N3O2S; copper diacetate In chloroform at -10℃; for 72h; Inert atmosphere; Schlenk technique; Sealed tube; Molecular sieve; enantioselective reaction;99%
Togni's reagent
887144-97-0

Togni's reagent

(E)-1-(3-bromophenyl)-3-phenylbut-3-en-1-one oxime

(E)-1-(3-bromophenyl)-3-phenylbut-3-en-1-one oxime

(S)-3-(3-bromophenyl)-5-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

(S)-3-(3-bromophenyl)-5-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

Conditions
ConditionsYield
With C30H39N3O2S; copper diacetate In chloroform at -10℃; for 72h; Inert atmosphere; Schlenk technique; Sealed tube; Molecular sieve; enantioselective reaction;99%
Togni's reagent
887144-97-0

Togni's reagent

(E)-3-phenyl-1-(thiophen-3-yl)but-3-en-1-one oxime

(E)-3-phenyl-1-(thiophen-3-yl)but-3-en-1-one oxime

(S)-5-phenyl-3-(thiophen-3-yl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

(S)-5-phenyl-3-(thiophen-3-yl)-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole

Conditions
ConditionsYield
With C30H39N3O2S; copper diacetate In chloroform at -10℃; for 72h; Inert atmosphere; Schlenk technique; Sealed tube; Molecular sieve; enantioselective reaction;99%
Togni's reagent
887144-97-0

Togni's reagent

benzyl (S)-3-methyl-2-oxo-5-(trifluoromethoxy)indoline-1-carboxylate

benzyl (S)-3-methyl-2-oxo-5-(trifluoromethoxy)indoline-1-carboxylate

benzyl (R)-3-methyl-2-oxo-5-(trifluoromethoxy)-3-(trifluoromethyl)indoline-1-carboxylate

benzyl (R)-3-methyl-2-oxo-5-(trifluoromethoxy)-3-(trifluoromethyl)indoline-1-carboxylate

Conditions
ConditionsYield
Stage #1: benzyl (S)-3-methyl-2-oxo-5-(trifluoromethoxy)indoline-1-carboxylate With C25H23N3O4; magnesium bromide ethyl etherate In dichloromethane at 20℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: Togni's reagent In dichloromethane at -78 - 20℃; for 19h; Schlenk technique; Inert atmosphere; enantioselective reaction;
99%
Togni's reagent
887144-97-0

Togni's reagent

styrene
292638-84-7

styrene

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

1-(4-chlorophenyl)-4,4,4-trifluoro-2-phenylbutan-1-one

1-(4-chlorophenyl)-4,4,4-trifluoro-2-phenylbutan-1-one

Conditions
ConditionsYield
With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate In acetonitrile at 60℃; for 12h; Schlenk technique; Inert atmosphere;99%
With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate In dichloromethane; water at 25℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere; Sealed tube;84%
Togni's reagent
887144-97-0

Togni's reagent

styrene
292638-84-7

styrene

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

1-(4-bromophenyl)-4,4,4-trifluoro-2-phenylbutan-1-one

1-(4-bromophenyl)-4,4,4-trifluoro-2-phenylbutan-1-one

Conditions
ConditionsYield
With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate In acetonitrile at 60℃; for 12h; Schlenk technique; Inert atmosphere;99%
Togni's reagent
887144-97-0

Togni's reagent

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

vinyl ester of phenylacetic acid
18120-64-4

vinyl ester of phenylacetic acid

C12H10F3NO2

C12H10F3NO2

Conditions
ConditionsYield
With carbon tetrabromide; C43H38N2O2; copper (I) acetate In tert-butyl methyl ether at -20℃; for 12h; Inert atmosphere; Sealed tube; enantioselective reaction;99%
Togni's reagent
887144-97-0

Togni's reagent

(4-butylphenyl)acetylene
79887-09-5

(4-butylphenyl)acetylene

1-butyl-4-(3,3,3-trifluoroprop-1-ynyl)benzene
1361988-15-9

1-butyl-4-(3,3,3-trifluoroprop-1-ynyl)benzene

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; potassium hydrogencarbonate In dichloromethane at 20℃; for 18h; Inert atmosphere;98%
Togni's reagent
887144-97-0

Togni's reagent

1-bromo-4-ethenyl-benzene
2039-82-9

1-bromo-4-ethenyl-benzene

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2-(4-bromophenyl)-4,4,4-trifluorobutanenitrile

2-(4-bromophenyl)-4,4,4-trifluorobutanenitrile

Conditions
ConditionsYield
With (2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)CuBr In dimethyl sulfoxide at 20℃; for 0.5h; Inert atmosphere;98%
Togni's reagent
887144-97-0

Togni's reagent

4-n-chlorophenylacetylene
873-73-4

4-n-chlorophenylacetylene

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2564-83-2, 45842-10-2

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

2,2,6,6-tetramethyl-1-(trifluoromethoxy)piperidine
1335135-19-7

2,2,6,6-tetramethyl-1-(trifluoromethoxy)piperidine

Conditions
ConditionsYield
With trimethylsilylazide; copper(I) bromide In methanol at 20℃; for 8h; Sealed tube; Inert atmosphere;98%
Togni's reagent
887144-97-0

Togni's reagent

trimethyl((1-(octyloxy)vinyl)oxy)silane
135066-77-2

trimethyl((1-(octyloxy)vinyl)oxy)silane

Octyl 3,3,3-trifluoropropanoate
116044-36-1

Octyl 3,3,3-trifluoropropanoate

Conditions
ConditionsYield
With trimethylsilyl bis(trifluoromethanesulfonyl)imide In dichloromethane at -78 - 20℃; for 19h; Inert atmosphere;98%
Togni's reagent
887144-97-0

Togni's reagent

trans-p-methylcinnamic acid
1866-39-3

trans-p-methylcinnamic acid

(E)-1-methyl-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene
80959-78-0, 78622-56-7

(E)-1-methyl-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 24h; Reagent/catalyst; Solvent; Temperature; stereoselective reaction;98%
Togni's reagent
887144-97-0

Togni's reagent

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2564-83-2, 45842-10-2

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

2,2,6,6-tetramethyl-1-(trifluoromethoxy)piperidine
1335135-19-7

2,2,6,6-tetramethyl-1-(trifluoromethoxy)piperidine

Conditions
ConditionsYield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; trimethylsilyl cyanide; (3aR,3a'R,8aS,8a'S)-2,2'-(cyclopentane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole); 2-(pent-4-en-2-yn-1-yl)isoindoline-1,3-dione In acetonitrile at -15 - 20℃; for 2.5h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;98%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In acetone at 25℃; for 24h;80%
With α-phenylacrylanilide; copper(II) bis(trifluoromethanesulfonate); p-tert-butylphenylboronic acid; (4S,4'S)-2,2'-(1,3-diphenylpropane-2,2-diyl)-bis(4-benzyl-4,5-dihydrooxazole) In methanol at 0℃; for 72h; Inert atmosphere; Sealed tube;79%
Togni's reagent
887144-97-0

Togni's reagent

6-benzyl-1-methyl-7-((trimethylsilyl)oxy)-2,3,4,5-tetrahydro-1H-azepine

6-benzyl-1-methyl-7-((trimethylsilyl)oxy)-2,3,4,5-tetrahydro-1H-azepine

3-benzyl-1-methyl-3-(trifluoromethyl)azepan-2-one

3-benzyl-1-methyl-3-(trifluoromethyl)azepan-2-one

Conditions
ConditionsYield
With trimethylsilyl bis(trifluoromethanesulfonyl)imide In dichloromethane at -78 - 20℃; for 19h; Schlenk technique; Inert atmosphere;98%
Togni's reagent
887144-97-0

Togni's reagent

diphenyl ditelluride
32294-60-3

diphenyl ditelluride

1-iodo-3,3-dimethyl-1-phenyl-1,3-dihydro-2,1λ4-benzoxatellurole

1-iodo-3,3-dimethyl-1-phenyl-1,3-dihydro-2,1λ4-benzoxatellurole

Conditions
ConditionsYield
at 80℃; Sealed tube; Inert atmosphere;98%
Togni's reagent
887144-97-0

Togni's reagent

9-vinyl-9H-carbazole
1484-13-5

9-vinyl-9H-carbazole

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

C22H15ClF3NO

C22H15ClF3NO

Conditions
ConditionsYield
With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate In dichloromethane; water at 25℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;98%
Togni's reagent
887144-97-0

Togni's reagent

N-vinylphthalimide
3485-84-5

N-vinylphthalimide

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

C12H7F3N2O2

C12H7F3N2O2

Conditions
ConditionsYield
With carbon tetrabromide; C43H38N2O2; copper (I) acetate In tert-butyl methyl ether at -20℃; for 12h; Inert atmosphere; Sealed tube; enantioselective reaction;98%
Togni's reagent
887144-97-0

Togni's reagent

1-ethenyl-2-pyrrolidinone
88-12-0

1-ethenyl-2-pyrrolidinone

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

A

C8H9F3N2O

C8H9F3N2O

B

C8H9F3N2O

C8H9F3N2O

Conditions
ConditionsYield
With carbon tetrabromide; C43H38N2O2; copper (I) acetate In tert-butyl methyl ether at -20℃; for 12h; Inert atmosphere; Sealed tube; Overall yield = 96 percent; Overall yield = 39.5 mg; enantioselective reaction;A 98%
B n/a
Togni's reagent
887144-97-0

Togni's reagent

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

vinyl benzoate
769-78-8

vinyl benzoate

C11H8F3NO2

C11H8F3NO2

Conditions
ConditionsYield
With carbon tetrabromide; C43H38N2O2; copper (I) acetate In tert-butyl methyl ether at -20℃; for 12h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Sealed tube; enantioselective reaction;98%
Togni's reagent
887144-97-0

Togni's reagent

trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

N-benzoylethyleneimine
13313-25-2

N-benzoylethyleneimine

C11H9F3N2O

C11H9F3N2O

Conditions
ConditionsYield
With carbon tetrabromide; C25H26N2O2; copper (I) acetate In tert-butyl methyl ether at -20℃; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; Sealed tube; enantioselective reaction;98%
Togni's reagent
887144-97-0

Togni's reagent

ethyl (E)-2-(2,2-diphenylhydrazono)acetate

ethyl (E)-2-(2,2-diphenylhydrazono)acetate

ethyl (E)-2-(2,2-diphenylhydrazono)-3,3,3-trifluoropropanoate

ethyl (E)-2-(2,2-diphenylhydrazono)-3,3,3-trifluoropropanoate

Conditions
ConditionsYield
With copper(l) chloride In chloroform at 25℃; for 2h; Inert atmosphere; Sealed tube;97%
Togni's reagent
887144-97-0

Togni's reagent

5-benzyl-1-methyl-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydropyridine

5-benzyl-1-methyl-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydropyridine

3-benzyl-1-methyl-3-(trifluoromethyl)piperidin-2-one

3-benzyl-1-methyl-3-(trifluoromethyl)piperidin-2-one

Conditions
ConditionsYield
With trimethylsilyl bis(trifluoromethanesulfonyl)imide In dichloromethane at -78 - 20℃; for 19h; Reagent/catalyst; Schlenk technique; Inert atmosphere;97%
Togni's reagent
887144-97-0

Togni's reagent

tert-butyl (R)-3-(4-fluorobenzyl)-2-oxo-3-(trifluoromethyl)indoline-1-carboxylate

tert-butyl (R)-3-(4-fluorobenzyl)-2-oxo-3-(trifluoromethyl)indoline-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl 3-(4-fluorobenzyl)-2-oxoindoline-1-carboxylate With magnesium bromide ethyl etherate; {3aS-[2(3'aR*,9'bS*),3aα,9bα]}-2,2'-(2,6-pyridinediyl)bis[3a,4,5,9b-tetrahydronaphth[1,2-d]oxazole] In dichloromethane at 20℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: Togni's reagent In dichloromethane at -78 - 20℃; for 19h; Catalytic behavior; Reagent/catalyst; Schlenk technique; Inert atmosphere; enantioselective reaction;
97%
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