886372-63-0

Basic information

• Product Name: 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE
• Synonyms: 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE;3-AMINO-5-FLUORO-6-METHOXYPYRIDINE;5-fluoro-6-methoxypyridin-3-amine;5-Fluoro-6-methoxy-3-pyridinamine
• CAS NO: 886372-63-0
• Molecular Formula: C₆H₇FN₂O
• Molecular Weight: 142.1309832
• Product Categories: Fluorine series
• Mol File: 886372-63-0.mol

Chemical Properties

• Boiling Point: 255.068°C at 760 mmHg
• Flash Point: 108.062°C
• Appearance: /
• Density: 1.256g/cm³
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.16±0.10(Predicted)
• CAS DataBase Reference: 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE(886372-63-0)
• EPA Substance Registry System: 5-FLUORO-6-METHOXY-PYRIDIN-3-YLAMINE(886372-63-0)

Safety Data

• Hazardous Substances Data: 886372-63-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-6-methoxy-pyridin-3-ylamine is used as an intermediate for the synthesis of various bioactive molecules and drugs. Its unique structure and functional groups make it a valuable component in the development of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-Fluoro-6-methoxy-pyridin-3-ylamine may have potential applications in the design and synthesis of new drugs. Its presence of a fluorine atom and methoxy group can contribute to the modification of pharmacokinetic and pharmacodynamic properties of the resulting compounds.
Used in Organic Synthesis and Chemical Research:
5-Fluoro-6-methoxy-pyridin-3-ylamine may also be utilized as a building block or reagent in organic synthesis and chemical research. Its versatile structure allows for further functionalization and exploration of new chemical reactions, leading to the discovery of new compounds with potential applications in various industries.

InChI:InChI=1/C6H7FN2O/c1-10-6-5(7)2-4(8)3-9-6/h2-3H,8H2,1H3

Upstream product

• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 

Downstream Products

• 1253575-42-6 4-(2-(5-fluoro-6-methoxypyridin-3-ylamino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine 
• 1253571-14-0 5-(4-(bis(4-methoxybenzyl)-amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)nicotinaldehyde 
• 1253571-15-1 1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)ethanol 
• 1253575-95-9 1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)ethyl methanesulfonate 
• 1253571-16-2 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine 
• 1396085-99-6 (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate 
• 1253575-91-5 (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate 
• 1253575-93-7 1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)ethanone 
• 1253575-96-0 (S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate 
• 1253575-97-1 (S)-tert-butyl 4-((R)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)ethyl)-3-methylpiperazine-1-carboxylate 
• 1396087-06-1 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(prop-1-en-2-yl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine 
• 1396087-13-0 4-(5-(2-azidopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine 
• 1396087-19-6 4-(5-(2-aminopropan-2-yl)-2-((5-fluoro-6-methoxypyridin-3-yl)-amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine 
• 1396087-78-7 4-(2-((5-fluoro-6-methoxypyridin-3-yl)amino)-5-(2-(4-(methylsulfonyl)piperazin-1-yl)-propan-2-yl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine 

Relevant articles and documents

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.