- DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATIONS THEREOF
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A deuterium atom-substituted indole formamide derivative, a preparation method therefor, and medical applications thereof. Specifically, the present invention relates to a deuterium atom-substituted indole formamide derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and uses of the derivative serving as an ROR agonist and uses of the derivative in preventing and/or treating tumors or cancers, definitions of substituent groups in general formula (I) being same as definitions in the specification.
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Paragraph 0101; 0108; 0110; 0112
(2020/08/01)
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- Hydrophilic group-substituted indole carboxamide derivative, preparation method thereof and application of hydrophilic group-substituted indole carboxamide derivative to medicine
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The invention relates to a hydrophilic group-substituted indole carboxamide derivative, a preparation method thereof and application of the hydrophilic group-substituted indole carboxamide derivativeto medicine, particularly to a hydrophilic group-substituted indole carboxamide derivative shown as the formula (I), a preparation method thereof and a drug composition comprising the hydrophilic group-substituted indole carboxamide derivative. Besides, the invention also relates to application of the hydrophilic group-substituted indole carboxamide derivative as an ROR (retinoid-related orphan receptors) agonist as well as to preventing and/or treating tumor or cancer. The substituent groups in the formula (1) are identical in definition in those in specifications.
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Paragraph 0230-0232; 0236-0238
(2019/04/09)
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