886498-98-2

Basic information

• Product Name: 2,6-difluoro-4-methoxyphenylacetic acid
• Synonyms: 2-(2,6-difluoro-4-Methoxyphenyl)acetic acid;2,6-Didifluoro-4-Methoxyphenylacetic acid
• CAS NO: 886498-98-2
• Molecular Formula: C₉H₈F₂O₃
• Molecular Weight: 202.15
• Mol File: 886498-98-2.mol

Chemical Properties

• Melting Point: 138-141℃
• Boiling Point: 269.4 °C at 760 mmHg
• Flash Point: 116.7 °C
• Appearance: /
• Density: 1.354 g/cm³
• CAS DataBase Reference: 2,6-difluoro-4-methoxyphenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-difluoro-4-methoxyphenylacetic acid(886498-98-2)
• EPA Substance Registry System: 2,6-difluoro-4-methoxyphenylacetic acid(886498-98-2)

Safety Data

• Hazardous Substances Data: 886498-98-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2,6-difluoro-4-methoxyphenylacetic acid is used as a building block for the synthesis of various drugs, contributing to the development of new pharmaceuticals with diverse therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2,6-difluoro-4-methoxyphenylacetic acid is utilized as an intermediate for the production of agricultural chemicals, enhancing crop protection and yield.
Used in Enzyme Inhibition:
2,6-difluoro-4-methoxyphenylacetic acid is used as an enzyme inhibitor for 15-hydroxyprostaglandin dehydrogenase, playing a significant role in the regulation of prostaglandin levels, which can have implications in various physiological processes and conditions.
Used in Non-Steroidal Anti-Inflammatory Drug (NSAID) Production:
2,6-difluoro-4-methoxyphenylacetic acid is used as a key component in the production of NSAIDs, where it contributes to the modulation of inflammatory responses, providing relief from inflammation and pain.
Used in Modulation of Inflammatory Responses:
2,6-difluoro-4-methoxyphenylacetic acid is employed in pharmaceuticals to modulate inflammatory responses, making it a valuable asset in the treatment of conditions characterized by inflammation.

Upstream product

• 244092-40-8 diethyl 2-(2,6-difluoro-4-methoxyphenyl)malonate 
• 1268822-63-4 2-(2,6-difluoro-4-methoxyphenyl)malonic acid 

Downstream Products

• 1268822-64-5 methyl 2-(2,6-difluoro-4-methoxyphenyl)acetate 
• 1268822-65-6 methyl 2-(2,6-difluoro-4-hydroxyphenyl)acetate 
• 1268822-66-7 methyl 2-[2,6-difluoro-4-(triisopropylsilyloxy)phenyl]acetate 
• 1268822-67-8 2-[2,6-difluoro-4-(triisopropylsilyloxy)phenyl]ethanol 
• 1268822-68-9 [4-(2-bromoethyl)-3,5-difluorophenoxy]triisopropylsilane 
• 1588944-87-9 2-(2,6-difluoro-4-hydroxyphenyl)-N ,N-dimethylacetamide 
• 1437779-17-3 1-(azetidin-1-yl)-2-(2,6-difluoro-4-hydroxyphenyl)ethanone 
• 1042703-34-3 2-(2,6-difluoro-4-hydroxyphenyl)acetic acid 
• 1268822-09-8 4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate 
• 1268822-08-7 4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile 
• 1437778-47-6 1-({2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetyl)azetidin-3-ol 
• 1437779-07-1 {2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid 
• 1437779-06-0 methyl {2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetate 
• 1268821-79-9 4-(2-((6-cyano-biphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)ethyl)-3,5-difluoro-phenyl sulfamate 

Relevant articles and documents

Synthesis and Structure-Activity Relationship Studies of Derivatives of the Dual Aromatase-Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate and its ortho-halogenated (F, Cl, Br) derivatives are first-generation dual aromatase and sulfatase inhibitors (DASIs). Structure-activity relationship studies were performed on these

AROMATASE INHIBITOR

There is provided a compound of formula (I) wherein Z is selected from N and CR22, wherein R22 is H or a bond with D, wherein D is selected from a bond, C=O, and linear or branched hydrocarbon groups having a carbon chain of from 1 t