886762-87-4

Basic information

• Product Name: 5,7-difluorochroman-4-amine
• Synonyms: 5,7-difluorochroman-4-amine;5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine;5,7-difluoro-3,4-dihydro-2H-chroMen-4-aMine;5,7-DIFLUOROCHROMAN-4-AMINE-HCL
• CAS NO: 886762-87-4
• Molecular Formula: C9H9F2NO
• Molecular Weight: 185.1706664
• Mol File: 886762-87-4.mol

Chemical Properties

• Boiling Point: 204℃
• Flash Point: 77℃
• Appearance: /
• Density: 1.292
• Vapor Pressure: 0.269mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5,7-difluorochroman-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-difluorochroman-4-amine(886762-87-4)
• EPA Substance Registry System: 5,7-difluorochroman-4-amine(886762-87-4)

Safety Data

• Hazardous Substances Data: 886762-87-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
5,7-Difluorochroman-4-amine is used as a reagent in the preparation of 2-amino-4-naphthylamino-6H-1,3,5-triazines, which are important compounds in the development of herbicides and plant growth regulators. Its fluorinated chroman structure contributes to the enhanced biological activity and selectivity of the resulting products.
Used in Pharmaceutical Industry:
5,7-Difluorochroman-4-amine is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those targeting central nervous system disorders, inflammation, and other conditions. Its unique structure allows for the development of novel drug candidates with improved potency, selectivity, and pharmacokinetic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 5,7-difluorochroman-4-amine plays a crucial role in the development of herbicides and plant growth regulators. Its incorporation into these compounds can lead to improved weed control and crop yield, as well as reduced environmental impact.
Used in Research and Development:
5,7-Difluorochroman-4-amine is also utilized in research and development settings for the exploration of new chemical reactions, synthetic pathways, and potential applications in various fields. Its unique properties make it an attractive candidate for further investigation and development.

InChI:InChI=1/C9H9F2NO/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7H,1-2,12H2

Upstream product

• 917248-51-2 5,7-difluoro-3,4-dihydro-2H-chromen-4-ol 
• 844648-22-2 5,7-difluorochroman-4-one 
• 1027098-55-0 4-azido-5,7-difluorochromane 

Relevant articles and documents

ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES

The application relates to 2-imino-hexahydropyrimidin-4-one derivatives of formula (I) which are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful for the treatment of malaria.

IMIDAZO [1, 2-A] PYRAZINE DERIVATIVES AND THEIR USE AS ACID PUMP ANTAGONISTS

This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.