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887115-56-2

5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine, also known as BEMP, is a heterocyclic aromatic compound with a molecular formula C7H6BrN3. It features a pyrazole ring fused to a pyridine ring, making it a versatile building block or intermediate in the synthesis of pharmaceuticals and agrochemicals. BEMP has been studied for its potential applications in medicinal chemistry, particularly as a scaffold for the development of new drug molecules, and is considered a useful and versatile chemical with a wide range of applications in the fields of chemistry and medicine.

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  • 887115-56-2 Structure

  • Basic information

    1. Product Name: 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
    2. Synonyms: 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine;5-Bromo-1-methyl-1H-pyraz...;5-bromo-1-methylpyrazolo[3,4-b]pyridine
    3. CAS NO:887115-56-2
    4. Molecular Formula: C7H6BrN3
    5. Molecular Weight: 212.04664
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 887115-56-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine(887115-56-2)
    11. EPA Substance Registry System: 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine(887115-56-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 887115-56-2(Hazardous Substances Data)

887115-56-2 Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine is used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products.
Used in Medicinal Chemistry Research:
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine is used as a scaffold in medicinal chemistry research for the design and synthesis of novel drug candidates with potential therapeutic properties.
Used in Chemical Synthesis:
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine is used as a versatile chemical intermediate in various chemical synthesis processes, enabling the creation of a wide range of compounds for different applications in the fields of chemistry and medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 887115-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,7,1,1 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 887115-56:
(8*8)+(7*8)+(6*7)+(5*1)+(4*1)+(3*5)+(2*5)+(1*6)=202
202 % 10 = 2
So 887115-56-2 is a valid CAS Registry Number.

887115-56-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromo-1-methylpyrazolo[3,4-b]pyridine

1.2 Other means of identification

Product number -
Other names 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:887115-56-2 SDS

887115-56-2Downstream Products

887115-56-2Relevant articles and documents

Solvent-Controlled, Site-Selective N-Alkylation Reactions of Azolo-Fused Ring Heterocycles at N1-, N2-, and N3-Positions, Including Pyrazolo[3,4- d]pyrimidines, Purines, [1,2,3]Triazolo[4,5]pyridines, and Related Deaza-Compounds

Bookser, Brett C.,Weinhouse, Michael I.,Burns, Aaron C.,Valiere, Andrew N.,Valdez, Lino J.,Stanczak, Pawel,Na, Jim,Rheingold, Arnold L.,Moore, Curtis E.,Dyck, Brian

, p. 6334 - 6353 (2018/06/01)

Alkylation of 4-methoxy-1H-pyrazolo[3,4-d]pyrimidine (1b) with iodomethane in THF using NaHMDS as base selectively provided N2-methyl product 4-methoxy-2-methyl-2H-pyrazolo[3,4-d]pyrimidine (3b) in an 8/1 ratio over N1-methyl product (2b). Interestingly, conducting the reaction in DMSO reversed selectivity to provide a 4/1 ratio of N1/N2 methylated products. Crystal structures of product 3b with N1 and N7 coordinated to sodium indicated a potential role for the latter reinforcing the N2-selectivity. Limits of selectivity were tested with 26 heterocycles which revealed that N7 was a controlling element directing alkylations to favor N2 for pyrazolo- and N3 for imidazo- and triazolo-fused ring heterocycles when conducted in THF. Use of 1H-detected pulsed field gradient-stimulated echo (PFG-STE) NMR defined the molecular weights of ionic reactive complexes. This data and DFT charge distribution calculations suggest close ion pairs (CIPs) or tight ion pairs (TIPs) control alkylation selectivity in THF and solvent-separated ion pairs (SIPs) are the reactive species in DMSO.

2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM

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Paragraph 0165; 0166, (2017/01/31)

The present invention provides a class of 2,4-substituted phenylene-1,5-diamine derivatives, having an inhibiting effect on EGFR tyrosine kinases, and pharmaceutically acceptable salt, stereoisomer, solvate or prodrug of said derivatives. See the description for the definition of each group in the formula. In addition, the present invention also discloses pharmaceutical compositions, pharmaceutically acceptable compositions and applications thereof.

NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS

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Page/Page column 54, (2011/12/14)

The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.

TGF-BETA INHIBITORS

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Page/Page column 24-25, (2008/06/13)

The present invention is directed to inhibitors of TGF-BETA of Formula (I).

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