5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine

Base Information

• Chemical Name: 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
• CAS No.: 887115-56-2
• Molecular Formula: C7H6BrN3
• Molecular Weight: 212.049
• Hs Code.: 2933990090
• Mol file: 887115-56-2.mol

Synonyms:5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine;5-Bromo-1-methyl-1H-pyraz...

Chemical Property of 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

• PSA: 30.71000
• LogP: 1.73080
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine

There total 4 articles about 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-bromo-7-azaindazole (875781-17-2,916257-29-9) + methyl iodide (74-88-4) → 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (887115-56-2)

Guidance literature:

5-bromo-7-azaindazole; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; at 25 ℃; Inert atmosphere;

Reference yield: 69.0%

5-bromo-7-azaindazole (875781-17-2,916257-29-9) + methyl iodide (74-88-4) → 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (887115-56-2) + 5-bromo-2-methyl-2H-pyrazolo[3,4-b]pyridine (1316852-65-9)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.8b00540

Reference yield: 27.0%

2-Bromo-malonaldehyde (2065-75-0) + 5-Amino-1-methylpyrazole (1192-21-8) → 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (887115-56-2)

Guidance literature:

With acetic acid; for 48h; Heating / reflux;

upstream raw materials:

2-Bromo-malonaldehyde

5-Amino-1-methylpyrazole

5-bromo-7-azaindazole

methyl iodide

Downstream raw materials:

C₃₀H₂₉F₃N₆O