Applying lipase catalysis to access the enantiomers of dorzolamide intermediates
The kinetic resolution of three dorzolamide intermediates has been studied in the presence of Burkholderia cepacia li-pase in organic solvents. All the stereoisomers of 6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol were prepared starting from the ra
Turcu, Mihaela C.,Rantapaju, Maria,Kanerva, Liisa T.
experimental part
p. 5594 - 5600
(2010/03/01)
An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507: 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran- 2-sulfonamide 7,7-dioxide hydrochloride
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Blacklock,Sohar,Butcher,Lamanec,Grabowski
p. 1672 - 1679
(2007/10/02)
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