887360-34-1Relevant articles and documents
Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit
Kounde, Cyrille S.,Yeo, Hui-Quan,Wang, Qing-Yin,Wan, Kah Fei,Dong, Hongping,Karuna, Ratna,Dix, Ina,Wagner, Trixie,Zou, Bin,Simon, Oliver,Bonamy, Ghislain M.C.,Yeung, Bryan K.S.,Yokokawa, Fumiaki
supporting information, p. 1385 - 1389 (2017/03/08)
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the identification of compound (S)-29, which exhibited potent anti-dengue activity in the cell-based assay across all four dengue serotypes with EC50??0.1?μM. Cross-resistant analysis confirmed that the virus NS4B protein remained the target of the new oxopiperazine analogs obtained via scaffold morphing from the HTS hit 4.
Iron(II) triflate as a catalyst for the synthesis of indoles by intramolecular C-H amination
Bonnamour, Julien,Bolm, Carsten
, p. 2012 - 2014 (2011/06/28)
A practical iron-catalyzed intramolecular C-H amination reaction and its application in the synthesis of indole derivatives are presented. As a catalyst, commercially available iron(II) triflate is used.
Intramolecular C-H amination reactions: Exploitation of the Rh 2(II)-catalyzed decomposition of azidoacrylates
Stokes, Benjamin J.,Dong, Huijun,Leslie, Brooke E.,Pumphrey, Ashley L.,Driver, Tom G.
, p. 7500 - 7501 (2008/02/09)
Rhodium(II) perfluorobutyrate-mediated decomposition of vinyl azides provides a new, mild entry into Rh2(II) nitrenoid chemistry. This methodology allows rapid access to a variety of complex, functionalized N-heterocycles in two steps from commercially available starting materials. Copyright
